Associate Professor

Institute of Life Sciences

Southeast University

Nanjing, China

Contact：

LiWenZheng Building,

Phone: 025-83790939

Email：zhangzc@seu.edu.cn

EducationandWork Experience

1998-2002, Nanjing University，Biochemistry, B.S.

2002-2005, Nanjing University，Biochemistry and Molecular Biology Major, M.S.

2005-2011, University of Texas Southwestern Medical Center at Dallas (USA), Cell Regulation Program, Ph.D

2011-2012, University of Texas Southwestern Medical Center at Dallas (USA), Department of Pharmacology, Postdoctoral Fellow

2012-present, Southeast University, Institute of Life Sciences，Associate Professor

Resarch Insterests:

Mental Retardation and neurodegenerative diseases affect a large population and put a huge burden on healthcare system. So far we know little about their pathological mechanism and lack effective treatments. They are still the major challenges in biomedical field. Studies on neuron development, synapse formation and maintenance, neurotransmission and circuit formation are the key to solve the problem.We use a combination of diverse approaches, such as biochemistry, molecular biology, cell biology, structural biology, bioinformatics and genetics, to study the regulation of gene expression, protein-protein interactions, intracellular trafficking of the macromolecules during these processes. We are trying to unveil the molecular mechanism of neuron development and neurodegeneration, and develop new treatment strategies for the diseases.

Publication:

1. Tian Y, Li T, Sun M, Wan D, Li Q, Li P, Zhang ZC, Han J*, Xie W*. Neuron. (2013), 77(2):311-22.

2. Zhang ZC, Chook YM*. Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS). Proc Natl Acad Sci U S A, (2012),109(30):12017-21

3. Etchin J§, Sun Q§., Kentsis A., Farmer A., Zhang ZC, Sanda T, Mansour MR, Barcelo C, McCauley D, Kauffman M, Shacham S, Christie AL, Kung A..L, Rodig S.J., Chook YM*, Look AT*. Anti-leukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia, (2012) Jul 31. doi: 10.1038/leu.2012.219. [Epub ahead of print] §Equal contributions.

4. Zhang ZC, Satterly N, Fontoura BMA and Chook YM*. Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1. Mol. Biol Cell, (2011), 22(23):4657-4668.

5. Qian F, Li YP, Sheng X, Zhang ZC, Song R, Dong W, Cao SX, Hua ZC, Xu Q*.(2007) PRL-3 siRNA Inhibits the Metastasis of B16-BL6 Mouse Melanoma Cells In Vitro and In Vivo. Mol Med, (2007),13(3-4):151-159.

6. Cansizoglu, AE, Lee BJ, Zhang ZC, Fontoura BMA and Chook YM*.  Structure-based design of a pathway-specific nuclear import inhibitor. Nat. Struc. & Mol. Biol, (2007), 14(5): 452-454.

7. Lee BJ, Cansizoglu AE, Suel KE, Louis TH, Zhang ZC and Chook YM*. Rules for nuclear localization sequence recognition by Karyopherinβ2. Cell, (2006), 126(3):543-558.

8. Qian F§, Zhang ZC§, Wu XF, Li YP, Xu Q*.  Interaction Between Integrin α5 and Fibronectin Is Required for Metastasis of B16F10 Melanoma cells. Biochem Biophys Res Commun, (2005), 333(4): 269-1275. §Equal contributions. 

9.Zhang ZC, Chook YM. Structural Analysis of Karyopherin-Mediated Nucleocytoplasmic Transport. In Nuclear Transport, Kehlenbach R (ed). Landes Bioscience, (2009)