柴人杰

发布者:吴志龙发布时间:2019-08-18浏览次数:36416

  

   

课题组长:

柴人杰,东南大学生命健康高等研究、生命科学与技术学院

Renjie Chai Ph.D., School of Life Science and Technology,

       Southeast University, Nanjing, China

研究领域:神经干细胞和内耳干细胞的转录调控机制;

听觉神经元和毛细胞再生。

地址:南京市玄武区四牌楼2号,东南大学李文正楼北231室,210096





研究组长简介:

柴人杰,198211月出生,东南大学首席教授、二级教授,东南大学生命健康高等研究院执行院长、生命科学与技术学院副院长。2004年本科毕业于中国科学技术大学,生物科学专业,导师施蕴渝院士。2009年博士毕业于美国Baylor大学,生物医学专业,导师丁家桓教授,博士期间获贝勒大学第六届学生研究成果讨论会优秀研究成果奖。2009年至2013年于Stanford大学医学院从事博士后工作,博士后期间作为项目负责人主持的课题获美国斯坦福大学医学院院长奖励基金和美国听觉健康基金会资助。20138月开始在东南大学生命科学与技术学院任教授,博士生导师。现任中国生物物理学会听觉、言语与交流分会会长;中国生理学会干细胞生理专业委员会副主委、候任主委;中国细胞生物学学会发育生物学分会副会长;中国生物医学工程学会干细胞工程技术分会副会长;中国听力医学发展基金会基础研究专家委员会主委和专家指导委员会常务委员;国际耳内科医师协会执委(Executive board member);中国医促会耳内科分会副主委听觉基础研究学组组长;中国生物医药产业链创新与转化联盟医疗器械分会会长;中国老年医学学会理事,耳科学分会常务委员;国家耳鼻咽喉疾病临床医学研究中心学术指导委员会委员;中国细胞生物学会青委会委员,干细胞分会委员;江苏省医学会听力学分会副会长;江苏省人才创新创业促进会副秘书长,常务理事;江苏省研究型医院学会青年科学家分会会长;江苏省发育生物学会常务理事和听觉科学专委会主委;江苏省双创联合会常务理事和生物医药专委会副秘书长;江苏省侨联侨界专家委员会常务委员(特聘专家);江苏省防聋治聋技术指导专家组委员。现任ESCI期刊American Journal of Stem Cells(AJSC) 执行主编 (Executive Editor-in-Chief)Frontiers in Cell and Developmental BiologyNeuroscience Bulletin、实用医院临床杂志副主编(Associate Editor),Fundamental ResearchAmerican Journal of Translational ResearchAJTR),Fundamental ResearchHearing ResearchFrontiers of MedicineGlobal Journal of OtolaryngologyEngineeringAnnals of Translational MedicineJournal of Otorhinolaryngology, Hearing and Balance MedicineOHBM)期刊编委(Editorial Board Member)Neural Plasticity Journal of Bio-X期刊Lead Guest Editor

先后作为项目或课题负责人主持科技部国家重点研发计划干细胞及转化研究重点专项,科技部青年973计划,中国科学院“器官重建与制造”A类战略性先导科技专项,国家自然科学基金委重点项目1项,重大集成项目1项,面上项目2项,江苏省重点研发计划社会发展项目,四川省科技计划重点研发项目,人力资源和社会保障部留学人员科技活动重点项目,教育部留学人员项目,全球二十强药企德国Boehringer Ingelheim 公司的500万元的Faculty Research Award和瑞士Novartis公司70万元Faculty Research Award15项课题。相关工作发表在Cell, Nature communications, Science Advances, PNASAutophagy, Advanced Materials, Advanced Science, Advanced Functional MaterialsBiomaterials, Biosensors and BioelectronicsACS Applied Materials & Interfaces,Redox Biology, Antioxidants & Redox Signaling, DevelopmentCellular and Molecular Life Sciences, Cell Death & Disease等有国际影响力的学术期刊上5发表通讯作者SCI论文130篇(总影响因子1246.38,平均影响因子9.33,其中IF>304篇,IF 10-3037篇),其中4篇论文被Faculty1000列为推荐文章,1篇论文入选Cell正刊年度最佳论文,13篇论文入选了ESI高被引论文,2篇论文入选热点论文,总他引6000余次,h-index 48作为主编出版2本中文耳鼻喉学科教材和一本英文专著,作为编者参编了韩济生院士主编的第四版神经科学教材,负责第六篇第四章听觉系统的撰写;研究成果也获得了第三届全国创新争先奖状,教育部霍英东教育基金会高等院校青年科学奖一等奖(第一完成人),中国青年科技奖(第一完成人),中华医学科技奖二等奖(第一完成人),江苏省青年科技奖(第一完成人),树兰医学青年奖(第一完成人),高等学校科学技术奖自然科学一等奖(第三完成人),江苏省医学科技奖一等奖(第二完成人),湖北省科学技术奖二等奖(第二完成人)和上海市技术发明一等奖(第九完成人),也获得了2022年度中国科协十大强国青年科学家,2020年度江苏省十大青年科技之星,江苏省五四青年奖章提名奖;申报了23项国家发明专利,授权了5项国家发明专利1项实用新型专利;另有国际会议大会发言8次,国际会议论文21篇,作为大会主席参与举办了三届中国听觉科学大会(第1,3,4届),作为分论坛主席主持了一届国际耳内科医师学会年会听觉异常与平衡障碍分论坛(第19届),主持了两届中国生物物理学会年会听觉研究分论坛(第15,16届),主持了两届中国神经科学学会年会听觉研究分论坛(第1213届)。

 

研究内容:长期致力于内耳毛细胞和神经元的再生和保护以及神经干细胞和内耳干细胞的转录调控机制的研究。主要研究内容包括:1.系统的研究了多种信号通路对于内耳干细胞和神经干细胞增殖和分化的转录调控机制;2.结合多基因协同调控,生物材料和电刺激,磁刺激等物理调控因素有效促进神经元和毛细胞的再生和听觉功能的部分重建;3通过调控免疫系统,自噬,线粒体功能和氧化应激有效的保护了噪音和药物导致的毛细胞损伤和听力损失。

 

代表性论著

专著:

1.  高下(主编),钱晓云(主编),柴人杰(主编),管莹(主编),人工耳蜗植入暨感音神经性耳聋医疗手册,东南大学出版社,196千字,ISBN 978-7-5641-8304-22020

2.  Huawei Li (Editor), Renjie ChaiEditor. Hearing Loss: Mechanisms, Prevention and Cure. Springer Nature, ISSN 0065-2598 ISSN 2214-8019 (electronic),Springer Nature 出版社,ISBN 978-981-13-6122-7 ISBN 978-981-13-6123-4 (eBook), Online Link: https://doi.org/10.1007/978-981-13-6123-4, Library of Congress Control Number: 20199335672019.

3.  柴人杰(主编),陈峰,陈杰,戴艳红,高下(主编),陆玲,麻晓峰,王俊国,钱晓云,杨烨,俞晨杰,张莎莎,周函,朱光洁,人工听觉技术概要,南京大学出版社, 352千字,ISBN 978-7-305-17890-02016

 

代表性期刊论文:

1.    Jie Zhao#, Hong Fu#, Jingjing Yu#, Weiqi Hong#, Xiaowen Tian#, Jieyu Qi#, Suyue Sun, Chang Zhao, ChaoWu, Zheng Xu, Lin Cheng, Renjie Chai*(并列通讯作者), Wei Yan*, Xiawei Wei*, Zhenhua Shao*. Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine. Nature Communications, 14(1):962, 2023 (IF:17.694)

2.    Hong Chen#, Hui Zhang#, Yanhong Dai#, Haofang Zhu, Guodong Hong, Chengwen Zhu,Xiaoyun Qian*, Renjie Chai*(并列通讯作者), Xia Gao*, and Yuanjin Zhao*. Magnetic Hydrogel Microrobots Delivery System forDeafness Prevention. Advanced Functional Materials, 2303011, 2023(IF:19.924)

3.    Yuhua Zhang#, Qiaojun Fang#, Hongfeng Wang#, Jieyu Qi, Shan Sun, Menghui Liao, Yunhao Wu, Yangnan Hu, Pei Jiang, Cheng Cheng , Xiaoyun Qian, Mingliang Tang, Wei Cao, Shang Xiang, Chen Zhang, Jianming Yang*, Xia Gao*, Zheng Ying*, Renjie Chai*(最后并列通讯作者).Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage. Autophagy, 19(1):75-91, 2023 (IF:13.391)

4.    Dong Liu#, Chun-hui Liang#, Bin Huang#, Xiao Zhuang#, Weiwei Cui, Li Yang, Yinghong Yang, Yudan Zhang, Xiaolong Fu, Xiaoju Zhang, Lutao Du, Wei Gu, Xiangdong Wang, Chengqian Yin*, Renjie Chai*(并列通讯作者), Bo Chu*. Tryptophan metabolism acts as a new anti-ferroptotic pathway to mediate tumour growth. Advanced Science, e2204006, 2023 (IF:17.521)

5.    Guodong Hong#, Xiaolong Fu#,*, Xin Chen#, Liyan Zhang#, Xuan Han, Shuqin Ding, Ziyi Liu, Liuli Bi, Wen Li, Miao Chang, Ruifeng Qiao, Siwei Guo, Hailong Tu, Renjie Chai*(最后并列通讯作者). Dyslexia-related hearing loss occurs mainly through the abnormal spontaneous electrical activity of spiral ganglion neurons. Advanced Science, e2205754, 2023 (IF:17.521)

6.    Xiaolong Fu#,*, Peifeng Wan#, Ling Lu#, Yingcui Wan, Ziyi Liu, Guodong Hong, Shengda Cao, Xiuli Bi, Jing Zhou, Ruifeng Qiao, Siwei Guo, Yu Xiao, Bingzheng Wang, Miao Chang, Wen Li, Peipei Li, Aizhen Zhang, Jin Sun, Renjie Chai*(并列通讯作者), Jiangang Gao*. Peroxisome deficiency in cochlear hair cells causes hearing loss by deregulating BK channels. Advanced Science, e2300402, 2023 (IF:17.521)

7.    Guoqiang Sun#, Yandong Zheng#, Xiaolong Fu#, Weiqi Zhang#, Jie Ren#,Shuai Ma, Shuhui Sun, Xiaojuan He, Qiaoran Wang, Zhejun Ji, FangCheng, Kaowen Yan, Ziyi Liu, Juan Carlos Izpisua Belmonte, Jing Qu*, SiWang*, Renjie Chai*(并列通讯作者),Guanghui Liu*. Single-cell transcriptomic Atlas of mouse cochlear aging. Protein & Cell,14(3):180-201, 2023(IF:15.328)

8.    Hui Zhang, Huan Wang, Baojie Wen, Ling Lu, Yuanjin Zhao*, Renjie Chai*(最后并列通讯作者). Ultrasound-responsive composited conductive silk conduits for peripheral nerve regeneration. Small Structures, 2300045, 2023 (IF: 11.343)

9.    Lin Shi#, Guodong Hong#, Chuntao Chen*, Xueqian Li, Heng Zhang, Renjie Chai*(并列通讯作者), Dongping Sun*. Growth of spiral ganglion neurons induced by graphene oxide/oxidized bacterial cellulose composite hydrogel. Carbohydrate Polymers,311:120749, 2023 (IF10.723

10.  Liyan Zhang#, Yuan Fang#, Fangzhi Tan#, Fangfang Guo#, Ziyu Zhang, Nianci Li, Qiuhan Sun, Jieyu Qi*, Renjie Chai*(最后并列通讯作者). AAV-Net1 facilitates the trans-differentiation of supporting cells into hair cells in the murine cochlea. Cellular and Molecular Life Sciences, 80(4):86, 2023. (IF: 9.234)

11.  Changling Xu#, Jieyu Qi#,*, Xiaojie Hu#, Liyan Zhang#, Qiuhan Sun, Nianci Li, Xin Chen, Fangfang Guo, Peina Wu*, Yi Shi*, Renjie Chai*(最后并列通讯作者). Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea. Cell Proliferation, e13458, 2023. (IF: 8.755)

12.  Xuechun Yang#, Jieyu Qi#, Liyan Zhang#, Fangzhi Tan#,Hongming Huang, Chunlai Xu, Yong Cui*, Renjie Chai*(并列通讯作者), Peina Wu*. The role of Espin in the stereocilia regeneration and protection in Atoh1‐overexpressed cochlear epithelium. Cell Proliferation, e13483, 2023. (IF: 8.755)

13.  Mingyu Xia#, Jiaoyao Ma#, Mingxuan Wu, Luo Guo, Yan Chen, GengLin Li, Shan Sun, Renjie Chai*(并列通讯作者), Huawei Li*, Wenyan Li*. Generation of innervated cochlear organoid recapitulates early development of auditory unit. Stem Cell Reports, 18(1):319-336, 2023(IF:7.294)

14.  Yuan Zhang#, Xiaolong Fu#*, Yiyuan Li#, Wen Li , Guodong Hong, Siwei Guo, Yu Xiao, Ziyi Liu, Shuqin Ding, Xiuli Bi, Fanglei Ye*, Jin Jin*, Renjie Chai*(最后并列通讯作者).Macrophage-mediated immune response aggravates hearing disfunction caused by the disorder of mitochondrial dynamics in cochlear hair cells.Human Molecular Genetics, 32(7):1137-1151, 2023(IF:5.121)

15.   Yangnan Hu#, Han Zhang#, Hao Wei#, Menghui Liao, Xiaoyan Chen, Jiayue Xing, Lian Duan, Cuntu Cheng, Weicheng Lu, Xuechun Yang, Peina Wu*, Huan Wang*, Jingdun Xie*, Renjie Chai*(最后并列通讯作者). Conductive PS inverse opals for regulating proliferation and differentiation of neural stem cells. Engineered Regeneration, 4(2),214-221, 2023 (IF:0)

16.  Guodong Hong#, Xiaolong Fu#, Jieyu Qi#, Buwei Shao#, Xuan Han, Yuan Fang, Shuang Liu, Cheng Cheng,Chengwen Zhu, Junyan Gao, Xia Gao, Jie Chen*, Ming Xia*, Wei Xiong*, Renjie Chai*(最后并列通讯作者).Dock4 Is Required for the Maintenance of Cochlear Hair Cells and Hearing Function. Fundamental Research, 11:40,559-573, 2023(IF:0)

17.  Lin Xia#, Xiaolong Zhao#, Xiangyu Ma#, Yangnan Hu, Yuan Zhang, Siyu Li, Jie Wang*, Yuanjin Zhao*, Renjie Chai*(最后并列通讯作者). Controllable growth of spiral ganglion neurons by magnetic colloidal nanochains. Nano Today, 44:101507, 2022(IF:18.962)

18.  Yong Tao#, Xiaoyi Liu#, Liu Yang#, Cenfeng Chu, Fangzhi Tan, Zehua Yu, Junzi Ke, Xiang Li, Xiaofei Zheng, Xingle Zhao, Jieyu Qi, Chao-Po Lin, Renjie Chai*(并列通讯作者), Guisheng Zhong*, Hao Wu*. AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration. Signal Transduction and Targeted Therapy, 7(1):109, 2022(IF:38.104)

19.  Xiaolong Fu, Peipei Li, Linqing Zhang,Yuning Song,Yachun An,Aizhen Zhang,Wenwen Liu,Chao Ye, Yuan Zhang, Rongyu Yue, Xiaoyang Sun, Renjie Chai*(并列通讯作者), Haibo Wang*,Jiangang Gao*. Activation of Rictor/mTORC2 signaling acts as a new pivotal strategy to protect against sensorineural hearing loss. PNAS, 119(10):e2107357119, 2022(IF:12.779)

20.  Lingna Guo#, Wenxuan Dai#, Zhengrong Xu#, Qiaoyi Liang, Eliot T. Miller, Shengju Li, Xia Gao, Maude W. Baldwin, Renjie Chai*(并列通讯作者), and Qian Li*.Evolution of brain-expressed biogenic amine receptors into olfactory trace amine-associated receptors. Molecular Biology and Evolution, 39(3):msac006,2022(IF:8.8)

21.      Zhong Zhang#, Gao Shan#, Yangnan Hu#,Xin Chen, Cheng Cheng, Xiaolong Fu, Shasha Zhang, Xinlin Wang, Yuwei Che, Chen Zhang, Renjie Chai*(唯一通讯作者).Ti3C2TxMXene Composite 3D Hydrogel Potentiates mTOR signaling to Promote the Generation of Functional Hair Cells in Cochlea Organoids. Advanced Science, e2203557, 2022 (IF:17.521)

22.  Shuai Wang#, Huilin Mao, Linghui Hou, Ziying Hu, Yao Wang, Tao Qi, Chen Tao, Yuan Yang, Chengdong Zhang, Miaomiao Li, Huihui Liu, Shijun Hu, Renjie Chai*(并列通讯作者), Yongming Wang*. Compact SchCas9 Recognizes the Simple NNGR PAM. Advanced Science, 9(4):e2104789, 2022 (IF:17.521)

23.  Lijun Cai, Cheng Zhao, Hanxu Chen, Lu Fan, Yuanjin Zhao*, Xiaoyun Qian*, Renjie Chai*(最后并列通讯作者). Suction-cup-inspired adhesive micromotors for drug delivery. Advanced Science,9(1):e2103384, 2022 (IF:17.521)

24.  Yangnan Hu#, Zhuoyue Chen#, Hongyang Wang#,Jiahui Guo, Jiaying Cai, Xiaoyan Chen, Hao Wei, Jieyu Qi, Qiuju Wang, Huisheng Liu*, Yuanjin Zhao*, Renjie Chai*(最后并列通讯作者).Conductive Nerve Guidance Conduits Based on Morpho Butterfly Wings for Peripheral Nerve Repair. ACS Nano, doi:10.1021/acsnano.1c11627, 2022(IF:18.027) (科技部网站推荐论文

25.  Menghui Liao#, Yangnan Hu#, Yuhua Zhang, Kaichen Wang, Qiaojun Fang, Yanru Qi, Yingbo Shen, Hong Cheng, Xiaolong Fu, Mingliang Tang*, Shan Sun*, Xia Gao*,Renjie Chai*(最后并列通讯作者).3D Ti3C2Tx MXene-matrigel with electroacoustic stimulation to promote the growth of spiral ganglion neurons. ACS Nano, DOI:10.1021/acsnano.2c06306, 2022(IF:18.027) (国家自然科学基金委推荐论文

26.  Shuai Wang#,Chen Tao#,Huilin Mao,Linghui Hou,Yao Wang,Tao Qi,Yuan Yang,Sang-Ging Ong,Shijun Hu*,Renjie Chai*(并列通讯作者),Yongming Wang*.Identification of SaCas9 orthologs containing a conserved serine residue that determines simple NNGG PAM recognition.PLoS Biology,20(11):e3001897, 2022(IF:9.593)

27.  Hui Zhang, Jiahui Guo, Yu Wang, Luoran Shang*, Renjie Chai*(并列通讯作者), Yuanjin Zhao*. Natural polymer-derived bio-scaffolds for peripheral nerve regeneration. Advanced Functional Materials, 2203829, 2022(IF:19.924)

28.  Hui Zhang, Han Zhang, Huan Wang, Yuanjin Zhao*, Renjie Chai*(最后并列通讯作者). Natural proteins-derived asymmetric porous conduit for peripheral nerve regeneration. Applied Materials Today,101431, 2022(IF:8.663)

29.  Maohua Wang#, Ying Dong#, Song Gao#, Zhenhua Zhong, Cheng Cheng, Ruiying Qiang, Yuhua Zhang, Xinyi Shi, Xiaoyun Qian, Xia Gao, Bing Guan*, Chenjie Yu*, Youjun Yu*, Renjie Chai*(最后并列通讯作者). Hippo/YAP signaling pathway protects against neomycin-induced hair cell damage in the mouse cochlea. Cellular and Molecular Life Sciences, 79(2):79, 2022(IF:9.207)

30.  Pei Jiang#, Xiangyu Ma#, Shanying Han#*, Leyao Ma#, Jingru Ai, Leilei Wu, Yuan Zhang, Hairong Xiao, Mengyao Tian, W. Andy Tao*, Shasha Zhang*, Renjie Chai*(最后并列通讯作者).Characterization of the microRNA transcriptomes and proteomics of cochlear tissue-derived small extracellular vesicles from mice of different ages after birth. Cellular and Molecular Life Sciences, 79(3):154, 2022(IF:9.207)

31.  Fuping Qian#, Guanyun Wei#, Yajing Gao#, Xin Wang, Jie Gong, Chao Guo, Xiaoning Wang, Xu Zhang, Jinxiang Zhao, Cheng Wang, Mengting Xu, Yuebo Hu, Guoli Yin, Jiahui Kang, Renjie Chai*(并列通讯作者), Gangcai Xie*, Dong Liu*. Singlecell RNAsequencing of zebrafsh hair cells reveals novel genes potentially involved in hearing loss. Cellular and Molecular Life Sciences, 79(7):385, 2022(IF:9.207)

32.  Rongrong Guo#, Miao Xiao#, Wanyu Zhao#, Shan Zhou, Yangnan Hu, Menghui Liao, Shengping Wang, Xiaowei Yang*, Renjie Chai*(并列通讯作者), Mingliang Tang*. 2D Ti3C2Tx MXene couples electrical stimulation to promote proliferation and neural differentiation of neural stem cells. Acta Biomaterialia, 139:105-117, 2022(IF:10.633) (ESI高被引论文)

33.  Yangnan Hu#, Wei Chen#, Haiyan Yin#, Xiaoyan Chen, Jiaying Cai, Jiamin Guo, Shan Zhou, Renjie Chai*(并列通讯作者), Mingliang Tang*.Super-aligned carbon nanotubes and GelMA hydrogel composite scaffolds promote spiral ganglion neuron growth and orientation.Materials Today Nano, 18,100181,     2022(IF:13.364)

34.  Yige Li#, Yangnan Hu#, Hao Wei#, Wei Cao#, Yanru Qi , Shan Zhou , Panpan Zhang , Huawei Li*, Geng‑Lin Li*, Renjie Chai*(最后并列通讯作者). Two-dimensional Ti3C2Tx MXene promotes electrophysiological maturation of neural circuits.Journal of Nanobiotechnology, 20(1):398, 2022(IF:9.429)

35.  Jiaying Cai#, Hui Zhang#, Yangnan Hu#, Zhichun Huang#, Yan Wang, Yu Xia, Xiaoyan Chen, Jiamin Guo, Hong Cheng, Lin Xia, Weicheng Lu, Chen Zhang, Jingdun Xie*, Huan Wang*, Renjie Chai*(最后并列通讯作者). GelMA-MXene hydrogel nerve conduits with microgrooves for spinal cord injury repair. Journal of Nanobiotechnology, 20(1):460, 2022(IF:9.429)

36.  Yuan Zhang#, Shasha Zhang#*, Han Zhou, Xiangyu Ma, Leilei Wu, Mengyao Tian, Siyu Li, Xiaoyun Qian*, Xia Gao*, Renjie Chai*(最后并列通讯作者). Dync1li1 is required for the survival of mammalian cochlear hair cells by regulating the transportation of autophagosomes. PLOS Genetics,18(6):e1010232, 2022(IF:6.02)

37.  Hao Wei#, Zhuoyue Chen#, Yangnan Hu#, Wei Cao#, Xiaofeng Ma, Chen Zhang, Xia Gao, Xiaoyun Qian*, Yuanjin Zhao*, Renjie Chai*(最后并列通讯作者). Topographically Conductive Butterfly Wing Substrates for Directed Spiral Ganglion Neuron Growth. Small, e2102062,2021 (IF: 15.153)(Small期刊当期封面论文,国家自然科学基金委推荐论文

38.  Changxiu Qu#, Chunyou Mao#, Peng Xiao#, Qingya Shen#, YaNi Zhong#, Fan Yang#,Dan-Dan Shen, Xiaona Tao, Huibing Zhang, Xu Yan, RuJia Zhao, Junyan He,Ying Guan, Chao Zhang, Guihua Hou, PengJu Zhang, Guige Hou, Zijian Li, Xiao Yu, Renjie Chai*(并列通讯作者), YouFei Guan, JinPeng Sun*, Yan Zhang*. Ligand recognition, unconventional activation,and G protein coupling of the prostaglandin E2receptor 2 (EP2). Science Advances,7(14):eabf1268,2021 (IF:14.957)

39.  Wenwen Liu#, Lei Xu#, Xue Wang, Daogong Zhang, Gaoying Sun, Man Wang, Mingming Wang, Yuechen Han*, Renjie Chai*(并列通讯作者), Haibo Wang*. PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.Autophagy, 1-23, 2021 (IF:13.391)(ESI高被引论文)

40.  Zuhong He#, Ming Li#, Qiaojun Fang#, Fuling Liao#, Shengyu Zou, Xia Wu, Haiying Sun, Xueyan Zhao, Yujuan Hu, Xiaoxiang Xu, Sen Chen, Yu Sun, Renjie Chai*(并列通讯作者), Weijia Kong*. FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway. Autophagy, 1-22, 2021 (IF:13.391) (ESI高被引论文)

41.  Yan Chen#, Yuyan Gu#, Yige Li#, GengLin Lia, Renjie Chai*(并列通讯作者), Wenyan Li*, Huawei Li*. Generation of mature and functional hair cells by co-expression of Gfi1, Pou4f3, and Atoh1 in the postnatal mouse cochlea. Cell Reports,35(3):109016, 2021 (IF:9.995)ESI高被引论文

42.  Cheng Zhao, Guopu Chen, Huan Wang, Yuanjin Zhao*, Renjie Chai*(最后并列通讯作者). Bio-inspired intestinal scavenger from microfluidic electrospray for detoxifying lipopolysaccharide. Bioactive Materials, 27;6(6):1653-1662, 2021 (IF:16.874)

43.      Yanru Yang, Bingbing Gao, Yangnan Hu, Hao Wei, Chen Zhang, Renjie Chai*(并列通讯作者), Zhongze Gu*. Ordered inverse-opal scaffold based on bionic transpiration to create a biomimetic spine. Nanoscale, 10.1039/D1NR00731A, 2021 (IF:8.307)

44.  Xiaolong Fu#, Yachun An#, Hongyang Wang#, Peipei Li, Jing Lin, Jia Yuan, Rongyu Yue, Yecheng Jin, Jiangang Gao*, Renjie Chai*(最后并列通讯作者). Deficiency of Klc2 induces low-frequency sensorineural hearing loss in C57BL/6J mice and human. Molecular Neurobiology,DOI:s12035-021-02422-w, 2021(IF:5.682)ESI高被引论文,热点论文

45.  Shanying Han#, Yueshuang Xu#, Jie Sun, Yufeng Liu, Yuanjin Zhao*, Weiguo Tao*, Renjie Chai*(最后并列通讯作者). Isolation and analysis of extra cellular vesicles in a Morpho butterfly wing-integrated micro vortex biochip. Biosensors and Bioelectronics, 154:112073, 2020 (IF:12.545)

46.  Jiahui Guo, Yunru Yu, Lingyu Sun, Zhuohao Zhang, Yuanjin Zhao*, Renjie Chai*(并列通讯作者), Keqing Shi*. Bio-inspired multicomponent carbon nanotube microfibers from microfluidics for supercapacitor. Chemical Engineering Journal 397:125517, 2020(IF:16.744)

47.  Zuhong He#, Shengyu Zou#, Ming Li, Fuling Liao, Xia Wu, Haiying Sun, Xueyan Zhao, Yujuan Hu, Dan Li, Xiaoxiang Xu, Sen Chen, Yu Sun*, Renjie Chai*(并列通讯作者), Weijia Kong*.The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways. Redox Biology,28:101364, 2020 (IF:10.787) (Faculty1000推荐,ESI高被引论文

48.  Shasha Zhang#, Yuan Zhang, Lingna Guo, Zhong Zhang, Ying Dong, Buwei Shao, Jieyu Qi, Han Zhou, Weijie Zhu, Xiaoqian Yan, Guodong Hong, Liyan Zhang, Xiaoli Zhang, Mingliang Tang, Chunjie Zhao, Xia Gao, Renjie Chai*唯一通讯作者). Knock-down of Foxg1 in Supporting Cells Increases the Transdifferentiation of Supporting Cells into Hair Cells in the Neonatal Mouse Cochlea.Cellular and Molecular Life Sciences, 77(7), 1401-1419, 2020(IF: 9.207)(Faculty1000推荐,ESI高被引论文

49.  Han Zhou#, Xiaoyun Qian#, Nana Xu, Shasha Zhang, Guangjie Zhu, Yuan Zhang, Dingding Liu, Cheng Cheng, Xiaocheng Zhu, Yongze Liu, Ling Lu, Jie Tang*, Renjie Chai*(并列通讯作者), Xia Gao*. Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice. Cell Death & Disease, 11(10):913, 2020(IF:9.685)

50.  Keqi, Fan#, Yiyuan Li#, Haoli Wang, Xintao Mao, Jinxin Guo, Xintao Mao, Fei, Wang, Lingjie Huang, Yining Li,Xiangyu Ma, Zhengjun Gao, Wei Chen, Dandan Qian, Wenjin Xue, Qian Cao, Lei Zhang, Li Shen,Long Zhang, Chao Tong, Jiangyan Zhong, Wei Lu, Ling Lu, Ke-ming Ren, Guisheng Zhong, Yuan Wang,Mingliang Tang, XinHua Feng, Renjie Chai*(并列通讯作者), Jin Jin*. Stress-induced metabolic disorder in peripheral CD4+ T cells leads to anxiety-like behavior. Cell, 179,864–879, 2019(IF: 66.850)(Faculty1000推荐Cell正刊年度最佳论文,国家自然科学基金委推荐论文

51.  Fangzhi Tan#*, Cenfeng Chu#, Jieyu Qi#, Wenyan Li#, Dan You, Ke Li, Xing Chen, Weidong Zhao, Cheng Cheng, Xiaoyi Liu, Yunbo Qiao, Bing Su, Shuijin He, Chao Zhong, Huawei Li*, Renjie Chai*(并列通讯作者), Guisheng Zhong*. AAV-ie enables safe and efficient gene transfer to inner ear cells. Nature Communications, 10(1):3733, 2019(IF: 17.694)国家自然科学基金委推荐论文

52.  Yan Liu#, Jieyu Qi#, Xin Chen#, Mingliang Tang#, Cenfeng Chu, Weijie Zhu, Hui Li, Cuiping Tian, Guang Yang, Chao Zhong, Zhang Ying, Guangjian Ni, Shuijin He*, Renjie Chai*(并列通讯作者), Guisheng Zhong*. Critical role of spectrin in hearing development and deafness. Science Advances, 5(4):eaav7803, 2019(IF: 14.957)

53.  Jinping Zhao#, Mingliang Tang#, Jing Cao, Dan Ye, Xudong Guo, Jiajie Xi, Yi Zhou, Yuchen Xia, Jing Qiao, Renjie Chai*(并列通讯作者), Xiaowei Yang* and Jiuhong Kang*. Structurally Tunable Reduced Graphene Oxide Substrate Maintains Mouse Embryonic Stem Cell Pluripotency. Advanced Science, 6(12):1802136, 2019 (IF:17.521)

54.  Wenwen Liu, Xiaochen Xu, Zhaomin Fan, Gaoying Sun, Yuechen Han, Daogong Zhang, Lei Xu, Mingming Wang, Xue Wang, Shasha Zhang, Mingliang Tang, Jianfeng Li, Renjie Chai*(并列通讯作者), Haibo Wang*.Wnt signaling activates TIGAR and protects against cisplatin-induced spiral ganglion neuron damage in the mouse cochlea.Antioxidants & Redox Signaling, 30(11):1389-1410, 2019 (IF:7.468)

55.  Jieyu Qi#, Yan Liu#, Cenfeng Chu, Xin Chen, Weijie Zhu, Yilai Shu, Shuijin He*, Renjie Chai*(并列通讯作者), Guisheng Zhong*. A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells. Cell Discovery, 5:12, 2019(IF:38.079)

56.  Cheng Cheng#, Yunfeng Wang#, Luo Guo#, Xiaoling Lu#, Weijie Zhu, Muhammad Waqas, Liyan Zhang, Ling Lu, Junyan Gao, Mingliang Tang, Xia Gao*, Huawei Li*, Renjie Chai*(最后并列通讯作者).Age-related transcriptome changes in Sox2+ supporting cells in the mouse cochlea.Stem cell research & therapy, 10(1):365, 2019 (IF:8.079)

57.  Zhongmin Liu#, Mingliang Tang#, Jinping Zhao, Renjie Chai*(并列通讯作者), Jiuhong Kang*. Looking into the Future: Towards Advanced Three-Dimensional Biomaterials for Stem Cell-Based Regenerative Medicine. Advanced Materials, 1705388, 2018(IF:32.086)

58.  Luoran Shang, Yunru Yu, Wei Gao, Yuetong Wang, Liangliang Qu, Ze Zhao, Renjie Chai*(并列通讯作者), Yuanjin Zhao*. Bio-inspired Anisotropic Wettability Surface from Dynamic Ferrofluid Assembled Templates. Advanced Functional Materials,1705802,2018(IF:19.924)

59.  Sana Shaikh, Fawad Rehman, Tianyu Du, Hui Jiang, Lihong Yin, Xuemei Wang*, Renjie Chai*(最后并列通讯作者). Real-time Multimodal Bioimaging of Cancer Cells and Exosomes through Biosynthesized Iridium and Iron Nanoclusters.ACS Applied Materials & Interfaces, 10(31):26056-26063, 2018 (IF:10.383) 

60.  Zuhong He#, Lingna Guo#, Yilai Shu#, Qiaojun Fang, Han Zhou, Yongze Liu, Dingding Liu, Ling Lu, Xiaoli Zhang, Xiaoqiong Ding, Dong Liu, Mingliang Tang, Weijia Kong, Suhua Sha, Huawei Li*, Xia Gao*, Renjie Chai*(最后并列通讯作者). Autophagy protects auditory hair cells against neomycin-induced damage. Autophagy, 2:1-21, 2017(IF: 13.391)

61.  Rongrong Guo#, Shasha Zhang#, Miao Xiao#, Fuping Qian, Zuhong He, Dan Li, Xiaoli Zhang,  Huawei Li, Xiaowei Yang, Ming Wang, Renjie Chai*(并列通讯作者), Mingliang Tang*.Accelerating bioelectric functional development of neural stem cells by graphene coupling: Implications for neural interfacing with conductive materials. Biomaterials, 106:193-204. 2016(IF:15.304)

62.  Liman Liu#, Yan Chen#, Jieyu Qi Yanping Zhang, Yingzi He, Wenli Ni, Wen Li, Shasha Zhang, Shan Sun, Makoto Taketo, Lei Wang, Renjie Chai*(并列通讯作者), Huawei Li*. Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea.Cell Death & Disease, 10;7:e2136, 2016(IF:9.685)

63.  Xin Wang, Chang Chun Ling, Liping Li, Yinyin Qin, Jialing Qi, Xiaoyu Liu, Bo You, Yunwei Shi, Jie Zhang, Qiu Jiang, Hui Xu, Cheng Sun, Yiwen You, Renjie Chai*(并列通讯作者, Dong Liu*.MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis. Cardiovascular Research, 110(1):140-50, 2016(IF:13.081)

64.  Tian Wang#, Renjie Chai#(并列第一作者), Grace Kim, Nicole Pham, Lina Jansson, Duc-Huy Nguyen, Bryan Kuo, Lindsey May, Jian Zuo, Lisa Cunningham, Alan Cheng*. Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatalmouse utricle. Nature Communications, 7;6:6613, 2015(IF: 17.694)

65.  Renjie Chai#并列第一作者, Bryan Kuo#, Tian Wang, Eric Liaw, Anping Xia, Taha Jana, Zhiyong Liu, Makoto M. Taketo, John Oghalai, Roeland Nusse, Jian Zuo*, Alan Cheng*. Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Proc Natl Acad Sci U S A, 109(21):8167-72, 2012 (IF:12.779)Faculty1000推荐)

 

三、    专利:

1.    柴人杰、陈蔚、张莎莎、程诚、高下;一种GPAEspinIkzf2小鼠模型的构建方法;专利号ZL202110194377.5,申请日期2021220日,授权时间2022816日;证书号第5388731号。

2.    柴人杰、赵远锦、胡扬楠、陈卓玥、魏浩、洪国栋;一种基于蝴蝶鳞翅的导电神经导管及其制备方法;专利号 ZL202111643052.7,申请日期20211229日,授权时间2022719日;证书号第5323789号。

3.    柴人杰、洪国栋、高下、唐明亮、付小龙;一种生物因子及其在促进内耳毛细胞再生上的应用;专利号 ZL2020110060861.0,申请日期20200930日,授权时间2022422日;证书号第5098878号。

4.    柴人杰、齐洁玉、钟桂生、谈方志、高下、唐明亮、付小龙;一种促进耳蜗毛细胞再生的肽段Tr及其应用;专利号 ZL202011059153.5,申请日期20200930日,授权时间20211214日;证书号第4850375

5.    钱晓云、祁姝琪、高下、孙晓安、柴人杰;氧化石墨烯人工耳蜗电极;专利号:ZL201920820468.3,申请时间2019603日,授权时间2020619日;证书号第10768061

6.    李华伟,于慧前,何英姿,孙珊,黎奥,柴人杰;赖氨酸特异性去甲基化酶1抑制剂的应用;专利号ZL201410058438.5, 申请时间20142 20日,授权时间2016824日;证书号第2192983

 

三、学术奖励:

1.    柴人杰、高下、靳津、钟桂生、李文妍、舒易来、齐洁玉、何水金、唐明亮、张莎莎、李异媛、程诚、陆玲、陈鑫,贺祖宏;通过程序化人工耳蜗手术及毛细胞再生治疗感音神经性耳聋的研究;中华医学科技奖二等奖(第一完成人)2023

2.    孙宇,柴人杰,贺祖宏,陶永,任冬冬;内耳发育障碍及基因干预机制;湖北省科学技术奖二等奖(第二完成人)2023

3.    柴人杰,第十七届中国青年科技奖,(第一完成人)2022

4.    柴人杰,2022年度中国科协十大强国青年科学家,(第一完成人)2022

5.    柴人杰,教育部霍英东教育基金会高等院校青年科学奖一等奖(第一完成人),2022

6.    柴人杰,第八届树兰医学青年奖(第一完成人),2021

7.    李华伟,李文妍,柴人杰,陈岩,孙珊,倪文力,鲁小玲,张彦平;基因重编程策略调控内耳干细胞增殖与分化;教育部高等学校科学研究优秀成果奖(科学技术)自然科学奖一等奖(第三完成人),2020

8.    李华伟,唐冬梅,蓝军,陈林,王武庆,陈兵,孙珊,王海涛,柴人杰,李树峰;数字化耳鸣诊疗装备的研发及推广;上海市技术发明一等奖(第九完成人),2020

9.    高下,柴人杰,钱晓云,陆玲,陈杰,朱光洁,杨烨,杨霞,程诚;感音神经性耳聋的基础与临床研究;江苏省科技进步奖三等奖(第二完成人),2020

10.  高下,柴人杰,钱晓云,陈杰,杨烨,陆玲,朱光洁,周函,杨霞;程序化人工耳蜗手术及感音神经性耳聋的相关分子机制研究;江苏省医学科技奖一等奖(第二完成人),2019

11.  柴人杰,江苏省青年科技奖(第一完成人),2020

12.  柴人杰,江苏省青年十大科技之星,2020