Experience

Principal Scientist

Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China

August 2011- present

Scientific Director

Analytical Genetics Technology Centre, Princess Margaret Hospital, Toronto, Canada; and Department of Genome Medicine, University of Toronto, Canada

June 2004 – March 2011

Research Associate II

Lap-Chee Tsui’s lab, Program of Genetics and Genomic Biology, Hospital for Sick Children Research Institute/University of Toronto, Canada

January 2002 – November 2003

Visiting Scientist

Lap-Chee Tsui’s lab, Program of Genetics and Genomic Biology, Hospital for Sick Children  Research Institute, Toronto, Canada

March – September 2001

Visiting Scientist

Bioinformatics Supercomputering Centre, Hospital for Sick Children, Toronto, Canada

January – July 2000

Senior Scientist

Department of Virus and Cancer, Danish Cancer Society, Aarhus, Denmark

January 2000 – December 2001

Visiting Scientist

Michael Karin’s lab, Department of Pharmacology, School of Medicine, University of California, San Diego, California, USA

March – July 1999

Junior Scientist

Department of Virus and Cancer, Danish Cancer Society, Aarhus, Denmark

January 1996 – December 1999

Scientific Assistant

Department of Virus and Cancer, Danish Cancer Society, Aarhus, Denmark

August 1992 – December 1995

Teaching and Research Assistant

Department of Infectious Diseases, Suzhou Medical College, China

September 1985 – July 1988

Education

Ph.D., School of  Public Health, University of Aarhus, Aarhus, Denmark

September 1994 –August 1998

M.S., Peking Union Medical College Graduate School, Beijing, China

September 1988 – July 1991

B.S., Division of Biochemistry, Department of Biology, Xiamen University, Xiamen, China

September 1981 – July 1985

Selected Publications

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

Liu X, Invernizzi P, Lu Y, Kosoy R, Lu Y, Bianchi I, Podda M, Xu C, Xie G, Macciardi F, Selmi C, Lupoli S, Shigeta R, Ransom M, Lleo A, Lee AT, Mason AL, Myers RP, Peltekian KM, Ghent CN, Bernuzzi F, Zuin M, Rosina F, Borghesio E, Floreani A, Lazzari R, Niro G, Andriulli A, Muratori L, Muratori P, Almasio PL, Andreone P, Margotti M, Brunetto M, Coco B, Alvaro D, Bragazzi MC, Marra F, Pisano A, Rigamonti C, Colombo M, Marzioni M, Benedetti A, Fabris L, Strazzabosco M, Portincasa P, Palmieri VO, Tiribelli C, Croce L, Bruno S, Rossi S, Vinci M, Prisco C, Mattalia A, Toniutto P, Picciotto A, Galli A, Ferrari C, Colombo S, Casella G, Morini L, Caporaso N, Colli A, Spinzi G, Montanari R, Gregersen PK, Heathcote EJ, Hirschfield GM, Siminovitch KA, Amos CI, Gershwin ME, Seldin MF.

Nature Genetics. 2010 Aug;42(8):658-60. Epub 2010 Jul 18.PMID: 20639880

Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.

Hirschfield GM, Liu X, Han Y, Gorlov IP, Lu Y, Xu C, Lu Y, Chen W, Juran BD, Coltescu C, Mason AL, Milkiewicz P, Myers RP, Odin JA, Luketic VA, Speiciene D, Vincent C, Levy C, Gregersen PK, Zhang J, Heathcote EJ, Lazaridis KN, Amos CI, Siminovitch KA.

Nature Genetics. 2010 Aug;42(8):655-7. Epub 2010 Jul 18.PMID: 20639879

Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.

Hirschfield GM*, Liu X*, Xu C, Lu Y, Xie G, Lu Y, Gu X, Walker EJ, Jing K, Juran BD, Mason AL, Myers RP, Peltekian KM, Ghent CN, Coltescu C, Atkinson EJ, Heathcote EJ, Lazaridis KN, Amos CI, Siminovitch KA. (co-first author)

New England J Medicine. 2009 Jun 11;360(24):2544-55. Epub 2009 May 20. PMID: 19458352 

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FA, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG; BIRAC Consortium, Barton A, Bowes J, Brouwer E, Burtt NP, Catanese JJ, Coblyn J, Coenen MJ, Costenbader KH, Criswell LA, Crusius JB, Cui J, de Bakker PI, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Lee AT, Liu X, Martin P, Morgan AW, Padyukov L, Posthumus MD, Radstake TR, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, van der Schoot CE, van Riel PL, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth BP; YEAR Consortium, Wijmenga C, Karlson EW, Toes RE, de Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM.

Nature Genetics.. 2010 Jun;42(6):508-14. Epub 2010 May 9.PMID: 20453842

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG; BIRAC Consortium, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW, Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P; YEAR Consortium, Altshuler D, Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA, Worthington J, Klareskog L, Gregersen PK, Daly MJ, Plenge RM.

Nature Genetics. 2009 Dec;41(12):1313-8. Epub 2009 Nov 8.PMID: 19898481