Jian Li

Associate Professor, PhD

Institute of Life Sciences

Southeast University

Email: jianli2014@seu.edu.cn

Jian Li is Associate Professor in Institute of Life Sciences, Southeast University. He is in charge of bioinformatics platform. Prior to joining Southeast University in 2014, Dr Li was visiting scientist, principle investigator and post-doctoral fellow in Department of Biomedicine, Aarhus University (Denmark) from 2008 to 2014. He received his bachelor degree of medicine from School of Clinical Medicine, Southeast University in 2001 and PhD at Human Genetics Institute, University of Aarhus in 2008.

Research Fields

● Bioinformatics & Systems of Biology

● Cancer Genomics

Research Projects

Data on biological systems is being generated at an unprecedented speed by new high-throughput molecular profiling techniques. Consequently, we are rapidly accumulating information about all aspects of cell function, such as DNA and protein sequences, gene expression levels and its regulations, epigenetic modifications, post-translational modifications, protein-protein interactions, metabolic pathways, protein complexes etc. No doubt, in Big Data Era, bioinformatics and systems biology are rapidly extending their applications in comprehensive biomedical research fields. Dr. Li is developing and applying bioinformatics tools to advance our understanding of cancer and autism. Major projects are as follows:

● Development of novel algorithms to understand tumorigenesis of skin tumors

● Meta-analysis of Autism associated genes

● Deepening understand of the human genome

● Gene networks in cancers

Selected Publications

1. Xue Lin, Jan Stenvang, Mads Kristoffer Heilskov Rasmussen, Shida Zhu, Guangxia Yang, Kirstine Belling, Claus Lindbjerg Andersen*, Jian Li*, Lars Bolund*, Nils Brünner*. The Potential Role of Alu Y in the Development of Resistance to SN38 (Irinotecan) and Oxaliplatin in Colon Cancer, BMC Genomics, 2015, 16:404. (* corresponding author)  

2. Xue Lin┼, Jian Li┼, Guangling Yin, Qian Zhao, Daniel Elias, Anne Lykkesfeldt, Jan Stenvang, Nils Brünner, Jun Wang, Huanming Yang, Lars Bolund, Henrik J. Ditzel: Integrative Analyses of Gene Expression and DNA Methylation Profiles in A Breast Cancer Cell Line Model of Tamoxifen-Resistance Indicate A Crucial Role of Cells with Stem-like Properties. Breast Cancer Res. 2013 Dec 19;15(6):R119. (┼co-first author)  

3. Jian Li, Xue Lin, Nils Brunner, Lars Bolund, Huanming Yang: Novel methods in the study of the breast cancer genome: towards a better understanding of the breast cancer disease. Journal of Cancer Therapy, 2012, 3, 797-809.

 4. Jian Li, Qian Zhao, Lars Bolund (2011): Computational methods for epigenetic analysis -the protocol of computational analysis for modified methylation-specific digital karyotyping (MMSDK) based on massively parallel sequencing. Methods Mol Biol, 791:313-28.

5. Steffen Durinck, Christine Ho, Nicholas J. Wang, Wilson Liao, Lakshmi R. Jakkula, Eric A. Collisson, Jennifer Pons, Sai-Wing Chan, Ernest T. Lam, Catherine Chu, Kyunghee Park, Sung-woo Hong, Joe S. Hur, Nam Huh, Isaac M. Neuhaus, Siegrid S. Yu, Roy T. Grekin, Theodora M. Mauro, James E. Cleaver, Pui-Yan Kwok, Philip E. Leboit, Gad Getz, Kristian Cibulskis, Jon C. Aster, Haiyan Huang, Elizabeth Purdom, Jian Li, Lars Bolund, Sarah T. Arron, Joe W. Gray, Paul Spellman, Raymond J. Cho (2011): Temporal dissection of tumorigenesis in primary cancers. Cancer Discovery, 1:137

6. Jian Li, Kai Wang, Fei Gao, Thomas D Jensen, Shengting Li, PM DeAngelis, S Kølvraa, C Proby, O Forslund, Lars Bolund, OPF Clausen (2012): Array comparative genomic hybridization of keratoacanthomas and squamous cell carcinomas: Different patterns of genetic aberrations and different recurrent aberrations suggest two distinct entities. J Invest Dermatol, 2012 Aug;132(8):2060-6. doi: 10.1038/jid.2012.104. Epub 2012 Apr 26.