张莎莎 副研究员 博士生导师
Email：zhangshasha@seu.edu.cn
办公地点：生命健康高等研究院（东南大学科技产业园（栖霞区））
个人简介：
2009年本科、2014年博士均毕业于清华大学生命科学学院，师从李蓬院士。2014年加入东南大学生命科学与技术学院，现任副研究员、博士生导师，兼任中大医院耳鼻喉头颈外科科研副主任、江苏省发育生物学会听觉专业委员会副主任委员、Sensory Neuroscience杂志青年编委等。先后入选江苏省333高层次人才培养工程、江苏省优青、江苏省科协青年科技人才托举工程，先后主持多项国家自然科学基金等国家级和省部级科研项目。
研究方向：
1.利用内耳干细胞再生功能性毛细胞，修复损伤的内耳结构、重建听觉功能
2.内耳靶向递送载体的工程化构建
近期代表性论文：(# co-first author; * corresponding author)
1. P. Jiang#, X. Ma#, S. Han#, L. Ma#, J. Ai, L. Wu, Y. Zhang, H. Xiao, M. Tian, W.. Tao*, S. Zhang*, and R. Chai*, Characterization of the microRNA transcriptomes and proteomics of cochlear tissue-derived small extracellular vesicles from mice of different ages after birth. Cellular and Molecular Life Sciences, 2022. 79(3): p. 154.2. S. Zhang#, Y. Zhang, L. Guo, Z. Zhang, Y. Dong, B. Shao, J. Qi, H. Zhou, W. Zhu, X. Yan, G. Hong, L. Zhang, X. Zhang, M. Tang, C. Zhao, X. Gao, R. Chai*. Knock-down of Foxg1 in Supporting Cells Increases the Transdifferentiation of Supporting Cells into Hair Cells in the Neonatal Mouse Cochlea. Cellular and Molecular Life Sciences, 77(7): 1401-1419, 2020
4. Y. Zhang#, S. Zhang#*, H. Zhou, X. Ma, L. Wu, M. Tian, S. Li, X. Qian*, X. Gao*, R. Chai*, Dync1li1 is required for the survival of mammalian cochlear hair cells by regulating the transportation of autophagosomes. PLOS Genetics, 2022. 18(6): p. e1010232.
5. Y. Chen#, R. Qiang#, Y. Zhang#, W. Cao#, L. Wu, P. Jiang, J. Ai, X. Ma, Y. Dong, X. Gao, H. Li*, L. Lu*, S. Zhang* and R. Chai*, The Expression and Roles of the Super Elongation Complex in Mouse Cochlear Lgr5+ Progenitor Cells. Frontiers in Cellular Neuroscience, 5: p. 735723, 2021.
6. J. Ai#, P. Jiang, J. Huang, H. Xiao, Y. Lin, M. Dai, Y. Wang, Y. Zhang, M. Tian, R. Chai, and S. Zhang*, The overexpression of Rps14 in Lgr5+ progenitor cells promotes hair cell regeneration in the postnatal mouse cochlea. Engineered Regeneration, 2023. 4(3): p. 328-336.
7. X. Ma#, S. Zhang#, S. Qin#, J. Guo, J. Yuan, R. Qiang, S. Zhou, W. Cao, J. Yang*, F. Ma*, R. Chai*. Transcriptomic and epigenomic analyses explore the potential role of H3K4me3 in neomycin-induced cochlear Lgr5+progenitor cell regeneration of hair cells. Human Cell. 2022. 35(4): p. 1030-1044.
