罗卓娟    教授

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办公地点：李文正楼南207室

教育和工作简历

1998至2002年，安徽大学，学士
2002至2005年，东南大学，硕士
2006至2011年，新加坡国立大学，博士
2011至2015年，Stowers Institute for Medical Research，博士后

2015年，     Feinberg School of Medicine, Northwestern University，博士后
2016至今，   东南大学，生命科学院研究院，教授

研究方向：表观遗传调控与疾病的发生发展

    越来越多的研究表明表观遗传调控异常与多种发育缺陷以及疾病之间息息相关，因而长期以来受到广泛的关注。基因组印记是指父源和母源的等位基因因表观遗传上的差异而造成的差异性表达。印记基因参与了众多关键的信号通路，调节细胞的增殖分化以及干细胞的全能性，在发育和疾病发生发展过程中起到重要的作用。由于其单基因表达的特点，印记基因表达水平更加容易受到遗传，表观遗传以及环境波动的影响，从而造成各种先天性疾病以及癌症。本实验室主要在多种疾病与发育模型中来探索印记基因的表达调控。这将为我们提供一个很好的模型来研究表观遗传修饰与转录因子介导的基因转录调控之间的相关性和因果性，也将为我们在疾病与发育异常中矫正基因表达缺陷做铺垫工作。

代表性论文：

1. Yue J#, Dai Q#, Hao S, Zhu S, Liu X, Tang Z, Li M, Fang H, Lin C*, Luo Z*. Suppression of the NTS-CPS1 regulatory axis by AFF1 in lung adenocarcinoma cells. J Biol Chem. 2021 Jan 22:100319. doi: 10.1016/j.jbc.2021.100319. Online ahead of print.

2. Du H#, Chen C#, Wang Y#, Yang Y, Che Z, Liu X, Meng S, Guo C, Xu M, Fang H, Wang F, Lin C*, Luo Z*. RNF219 interacts with CCR4-NOT in regulating stem cell differentiation. J Mol Cell Biol. 2021 Feb 15;12(11):894-905.

3. Guo C, Che Z, Yue J, Xie P, Hao S, Xie W, Luo Z*, Lin C*. ENL initiates multivalent phase separation of the super elongation complex (SEC) in controlling rapid transcriptional activation. Sci Adv. 2020 Apr 1;6(14):eaay4858. doi: 10.1126/sciadv.aay4858. eCollection 2020 Apr.

4. Luo Z#, Liu X, Xie H#, Wang Y, Lin C*. ZFP281 recruits MYC to active promoters in regulating transcriptional initiation and elongation. Mol Cell Biol. 2019 Sep 30. pii: MCB.00329-19. doi: 10.1128/MCB.00329-19.

5. Zhang Y, Wang C, Liu X, Yang Q, Ji H, Yang M, Xu M, Zhou Y, Xie W, Luo Z*, Lin C*. AFF3-DNA methylation interplay in maintaining the mono-allelic expression pattern of XIST in terminally differentiated cells. J Mol Cell Biol. 2018 Dec 7. doi: 10.1093/jmcb/mjy074.

6. Dai Q#, Shen Y#, Wang Y#, Wang X, Francisco JC, Luo Z, Lin C*. Striking a balance: regulation of transposable elements by Zfp281 and Mll2 in mouse embryonic stem cells. Nucleic Acids Res. 2017 Dec 1;45(21):12301-12310.

7.Francisco JC#, Dai Q#, Luo Z#, Wang Y, Chong RH, Tan YJ, Xie W, Lee GH, Lin C*. Transcriptional Elongation Control of Hepatitis B Virus Covalently Closed Circular DNA Transcription by Super Elongation Complex and BRD4.Mol Cell Biol. 2017 Sep 12;37(19). pii: e00040-17.

8.Wang Y#, Shen Y#, Dai Q, Yang Q, Zhang Y, Wang X, Xie W, Luo Z*, Lin C*. A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron.Nucleic Acids Res. 2017 Feb 17;45(3):1177-1185.

9.Luo Z, Lin C*. Enhancer, epigenetics, and human disease.Curr Opin Genet Dev. 2016 Feb;36:27-33.

10. Luo Z*, Lin C, Woodfin AR, Bartom ET, Gao X, Smith ER, Shilatifard A*. Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity.Genes Dev. 2016 Jan 1;30(1):92-101.

11.Luo Z, Gao X, Lin C, Smith ER, Marshall SA, Swanson SK, Florens L, Washburn MP, Shilatifard A*. Zic2 is an enhancer-binding factor required for embryonic stem cell specification.Mol Cell. 2015 Feb 19;57(4):685-694.

12.Wijeweera A, Haj M, Feldman A, Pnueli L, Luo Z, Melamed P*. Gonadotropin gene transcription is activated by menin-mediated effects on the chromatin.Biochim Biophys Acta. 2015 Mar;1849(3):328-41.

13.Lin C, Garruss AS, Luo Z, Guo F, Shilatifard A*. The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation.Cell. 2013 Jan 17;152(1-2):144-56.

14.Luo Z, Lin C, Shilatifard A*. The super elongation complex (SEC) family in transcriptional control.Nat Rev Mol Cell Biol. 2012 Sep;13(9):543-7.

15.Luo Z, Lin C, Guest E, Garrett AS, Mohaghegh N, Swanson S, Marshall S, Florens L, Washburn MP, Shilatifard A*. The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output.Mol Cell Biol. 2012 Jul;32(13):2608-17.

16.Luo Z, Wijeweera A, Oh Y, Liou YC, Melamed P*. Pin1 facilitates the phosphorylation-dependent ubiquitination of SF-1 to regulate gonadotropin beta-subunit gene transcription.Mol Cell Biol. 2010 Feb;30(3):745-63.