王福龙：副研究员
E-mail：fulongwang@seu.edu.cn
办公地点：东南大学江北校区 汇川楼B305
个人简介
本科毕业于东南大学，先后获得中国科学院大学硕士学位和英属哥伦比亚大学博士学位，得克萨斯大学MD安德森癌症中心和新墨西哥大学AIM中心从事博士后研究，2023年9月加入东南大学生命科学与技术学院，任副研究员。
研究方向
溶酶体损伤是一种在众多疾病中常见的细胞病变，这些疾病包括病原体感染（例如新冠病毒感染）、老年性疾病（比如神经退行性疾病）、以及环境污染（包括PM2.5微粒）相关的疾病。细胞如何在内外压力和刺激下维持包括溶酶体在内的内部稳态平衡是其最基础和本质的功能之一。本课题组旨在研究溶酶体在应激压力下与其他细胞器或细胞结构的联动机制以及自噬在其中的作用。
代表性论文
1. Paddar MA , Wang F , Trosdal ES, Hendrix E , He Y , Salemi M, Mudd M, Jia J, Duque TLA , Javed R, Phinney B, Deretic V. Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function. eLife. 2024
2. Lee CS, Shang R, Wang F, Khayambashi P, Wang H, Araujo G, Puri K, Vlodavsky I, Hussein B, Rodrigues B. Heparanase Stimulation of Physiologic Cardiac Hypertrophy Is Suppressed After Chronic Diabetes, Resulting in Cardiac Remodeling and Dysfunction. Diabetes. 2024 Aug 1;73(8):1300-1316.
3. Wang F, Trosdal ES, Paddar MA, Duque TLA, Allers L, Mudd M, Akepati PR, Javed R, Jia J, Salemi M, Phinney B, Deretic V. The role of ATG5 beyond Atg8ylation and autophagy. Autophagy. 2024 Feb;20(2):448-450.
4. Wang F, Peters R, Jia J, Mudd M, Salemi M, Allers L, Javed R, Duque TLA, Paddar MA, Trosdal ES, Phinney B, Deretic V. ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion. Developmental Cell. 2023 May 22;58(10):866-884.e8.
5. Deretic V, Wang F. Autophagy is part of the answer to tuberculosis. Nature Microbiology. 2023 May;8(5):762-763.
6. Jia J, Wang F, Bhujabal Z, Peters R, Mudd M, Duque T, Allers L, Javed R, Salemi M, Behrends C, Phinney B, Johansen T, Deretic V. Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage. Autophagy. 2023 Jun;19(6):1893-1895.
7. Javed R, Jain A, Duque T, Hendrix E, Paddar MA, Khan S, Claude-Taupin A, Jia J, Allers L, Wang F, Mudd M, Timmins G, Lidke K, Rusten TE, Akepati PR, He Y, Reggiori F, Eskelinen EL, Deretic V. Mammalian ATG8 proteins maintain autophagosomal membrane integrity through ESCRTs. The EMBO Journal.2023 Jun 5;:e112845.
8. Jia J, Wang F, Bhujabal Z, Peters R, Mudd M, Duque T, Allers L, Javed R, Salemi M, Behrends C, Phinney B, Johansen T, Deretic V. Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage. The Journal of Cell Biology. 2022 Nov 7;221(11).
9. Claude-Taupin A, Jia J, Bhujabal Z, Garfa-Traoré M, Kumar S, da Silva GPD, Javed R, Gu Y, Allers L, Peters R, Wang F, da Costa LJ, Pallikkuth S, Lidke KA, Mauthe M, Verlhac P, Uchiyama Y, Salemi M, Phinney B, Tooze SA, Mari MC, Johansen T, Reggiori F, Deretic V. ATG9A protects the plasma membrane from programmed and incidental permeabilization. Nature Cell Biology. 2021 Aug;23(8):846-858.
10. Wang F, Pulinilkunnil T, Flibotte S, Nislow C, Vlodavsky I, Hussein B, Rodrigues B. Heparanase protects the heart against chemical or ischemia/reperfusion injury. Journal of Molecular and Cellular Cardiology. 2019 Jun; 131:29-40.
11. Wang F, Jia J, Rodrigues B. Autophagy, metabolic disease, and pathogenesis of heart dysfunction. Canadian Journal of Cardiology. 2017 Jul;33(7):850-859.
12. Zhang D, Wang F, Lal N, Chiu AP, Wan A, Jia J, Bierende D, Flibotte S, Sinha S, Asadi A, Hu X, Taghizadeh F, Pulinilkunnil T, Nislow C, Vlodavsky I, Johnson JD, Kieffer TJ, Hussein B, Rodrigues B. Heparanase overexpression induces glucagon resistance and protects animals from chemically induced diabetes. Diabetes. 2017 Jan;66(1):45-57.
13. Wang F, Jia J, Lal N, Zhang D, Chiu AP, Wan A, Vlodavsky I, Hussein B, Rodrigues B. High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature. Cardiovascular Research. 2016 Dec;112(3):656-668.
完整文章列表：https://orcid.org/0000-0002-7083-9675
