谢维

发布者:许峰发布时间:2019-08-21浏览次数:20361




谢 维

教授、博士生导师
“发育与疾病相关基因”教育部重点实验室 主任
电话:025-83790970
E-mail:wei.xie@seu.edu.cn
Labweb: 
办公地点:南京市四牌楼2号,李文正楼北221
  

个人简介:

   19817月参加工作,19916月毕业于南京铁道医学院微生物学与免疫学专业,获硕士学位;199510月毕业于南京大学生物化学与分子生物学系,获博士学位。19971月至199812月在美国罗切斯特大学医学中心作博士后;19995月至20018月在加拿大多伦多大学附属多伦多病童医院博士后、访问学者。20019月作为教育部“CJ学者奖励计划特聘教授,受聘为东南大学基础医学院遗传学研究中心主任,博士生导师;2003年获准建设发育与疾病相关基因教育部重点实验室,任主任;20044月至200911月任东南大学基础医学院院长,200912月至201912月,任东南大学生命科学研究院院长。先后获得国家自然科学基金(面上、重点)、国家杰出青年科学基金、美国NIH基金(RO3)、国家“973”重大基础研究项目等资助。

研究方向:突触发育调控与认知疾病机制

   大脑通过约1015个突触连接而成的巨大通讯网络来进行信息处理、行使功能。突触通过自身的可塑性,传递、转变和完善信号。突触细胞粘附因子,通过连接突触前、后细胞,调节突触传递信号,并且通过形成特异性的突触功能来决定神经网络的特性。家系分析发现,人类突触细胞粘附因子基因发生突变与孤独症、精神分裂症等关联;基因组水平研究显示,包括孤独症、精神分裂症等多种认知性疾病,均存在编码突触分子,如CaherinsProtocadherinsL1CAMNeuroliginNeurexinCNTNAP2Contactins等的基因异常,但其致病机制不清。本研究组以神经元表面蛋白分子为研究对象,应用综合研究手段,结合模式生物,探索突触发生、成熟、环路形成以及在学习记忆等高级神经活动与行为中的作用,探讨其在遗传和表观遗传水平上的调控机制,为阐明其在相关的认知障碍与疾病中的作用奠定基础。

本课题组日常负责人联系方式:

吕卉卉:025-83790976 


近期代表性论文:


  1.  Moyi Li*, Yan Zhuang, Ranjan Batra, James D. Thomas, Mao Li, Curtis A Nutter, Marina M. Scotti, Helmut A Carter, Zhan Jun Wang, Xu Sheng Huang, Chuan Qiang Pu, Maurice S. Swanson, Wei Xie *. HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy. Proceedings of the National Academy of Sciences of the United States of America, 2020,117(10): 5472-5477.

  2.  Xuechen Zhou, Rui Hao, Chen Chen, Zhipeng Su, Linhong Zhao, Zhuojuan Luo, Wei Xie *. Rapid Delivery of Nanobodies/VHHs into Living Cells via Expressing In Vitro-Transcribed mRNA. Molecular Therapy - Methods & Clinical Development, 2020, 17:401-408.

  3.  Rui Mao, Rui Deng, Yan Wei, Lifang Han, Yanghong Meng, Wei Xie*, Zhengping Jia*. LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration. Mol Brain, 2019, 12(1):67.

  4. Guanglin Xing, Moyi Li, Menglong Rui, Nana Tao, Yan Zhuang, Huihui Lv, Junhai Han, Zhengping Jia*, and Wei Xie*. Neuroligin 1 Regulates Postsynaptic Actin Cytoskeleton via WAVE Regulatory Complex in Drosophila Neuromuscular Junction, eLife, 2018, 7:e30457.

  5. Jun Wu, Yao Tian, Guanglin Xing, Nana Tao, Huihui Lv, Junhai Han, Chengqi Lin and Wei Xie*. Proteolytic Maturation of Drosophila Neuroligin 3 by Tumor Necrosis Factor α-converting Enzyme in the Nervous System. Biochimica et Biophysica Acta(BBA) - General Subjects, 2018, 1862(3):440-450

  6. Xinwang Zhang, Menglong Rui, Guangming Gan, Cong Huang, Jukang Yi, Huihui Lv, Junhai Han, and Wei Xie*. Presynaptic Neuroligin 4 Positively Regulate Neuromuscular Synaptic Growth in Drosophila via BMP Signaling Pathway. The Journal of Biological Chemistry, 2017, 292(44):17991-18005.

  7. Menglong Rui, Jinjun Qian, Lijuan Liu, Yihan Cai, Huihui Lv, Junhai Han, Zhengping Jia, Wei Xie*. The neuronal protein neurexin directly interacts with the Scribble-Pix complex to stimulate F-actin assembly for presynaptic vesicle clustering. The Journal of Biological Chemistry, 2017, 292(35):14334-14348

  8. Renjun Tu, Jinjun Qian, Menglong Rui, Nana Tao, Mingkuan Sun, Yan Zhuang, Huihui Lv, Junhai Han, Moyi Li, Wei Xie*. Proteolytic cleavage is required for Neuroligin 2 maturation and function in Drosophila. Journal of Molecular Cell Biology, 2017, 9(3):231-242

  9. An Liu, Zikai Zhou, Rui Dang, Guiqing He, Celeste Leung, Daniel Pak, Zhengping Jia*, Wei Xie*. Neuroligin-1 regulates spines and synaptic plasticity via LIMK1/cofilin mediated actin reorganization. The Journal of Cell Biology, 2016, 212(4):449-463 (Cover Story, COMMENT:Karen A. NewellLitwa. Breaking down to build up: Neuroligin’s C-terminal domain strengthens the synapse. J. Cell Biol. 212, 375-377)

  10. Shuting Xia, Zikai Zhou, Celeste Leung, Yuehua Zhu, Xingxiu Pan, Maria Morena, Matthew N. Hill*, Wei Xie*, Zhengping Jia*. p21-Activated Kinase 1 Restricts Tonic Endocannabinoid Signaling in the Hippocampus. eLife, 2016, 5:e14653.

  11. Xingxiu Pan, Xinxia Chang, Celeste Leung, Zikai Zhou, Feng Cao, Wei Xie*, Zhengping Jia*. PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation. Molecular Brain, 2015, 8:36

  12. Guanglin Xing, Guangming Gan, Dandan Chen, Mingkuan Sun, Jukang Yi, Huihui Lv, Junhai Han, Wei Xie*. Drosophila Neuroligin3 Regulates Neuromuscular Junction Development and Synaptic Differentiation. The Journal of Biological Chemistry, 2014, 289(46):31867-31877 (Papers of the Week)

  13. Yi Li, Zikai Zhou, Xinwang Zhang, Huawei Tong, Peipei Li, Zichao Zhang, Zhengping Jia, Wei Xie* and Junhai Han*. Drosophila Neuroligin4 regulates sleep through modulating GABA transmission. The Journal of Neuroscience, 2013, 33(39):15545-15554

  14. Yao Tian, Yi Li, Mingkuan Sun, Wen Hu, Didi Wan, Jing Li, Junhai Han* and Wei Xie*. Neurexin Regulates Visual Function via Mediating Retinoid Transport to Promote Rhodopsin Maturation. Neuron, 2013, 77(2):311-322.

  15. Mingkuan Sun, Guanglin Xing, Liudi Yuan, Guangming Gan, David Knight, Sheila Irene With, Cui He, Junhai Han, Xiankun Zeng, Ming Fang, Gabrielle L. Boulianne*, Wei Xie*. Neuroligin2 Is Required for Synapse Development and Function at the Drosophila Neuromuscular Junction. The Journal of Neuroscience, 2011, 31(2):687-699 (This Week in The Journal)