李健

教授、博士研究生导师

电话：13052881142

Email: jianli2014@seu.edu.cn

办公地点：四牌楼校区李文正楼211室

个人简介：

1996年9月至2001年6月，就读于东南大学，获临床医学学士学位

2004年7月至2008年11月，就读于丹麦奥胡斯大学，获医学博士学位。导师：Lars Bolund

2008年11月至2014年7月，奥胡斯大学研究助理、博士后、主要研究员

2014年7月至2020年7月，受聘为东南大学副研究员

2020年7月至今，受聘为东南大学教授

担任江苏省生物信息学专委会秘书长，中国人工智能学会生物信息学与合成生命专委会委员，中国遗传学会高级会员，教育专委会委员。

研究方向：

生物信息学及系统生物学。主要从事：使用基因组学、人工智能研究复杂表型和疾病；纳米孔测序技术开发与应用；研究航天特因环境与适应机制；免疫信息学在公共卫生的应用等方面。主要成果发表于Briefings in Bioinformatics、Genomics Proteomics & Bioinformatics、Genome Research、Breast Cancer Research、J Invest Dermatol、Cancer Discovery等期刊。目前主持国家级课题5项，省部级项目10余项。共发表SCI论文40余篇。目前在授权发明专利7项，授权软件著作权12项，牵头团体标准1项。

近期代表性论文：

1. Chongxin Tao, Yun Bai, Jiang Chen, Jing Lu, Yan Bi, Jian Li (corresponding author), biosensors, 2024.

2. Pin Chen, Zepeng Sun, Jiawei Wang，Xinlong Liu, Yun Bai, Jiang Chen, Anna Liu, Feng Qiao, Yang Chen, Chenyan Yuan, Jingjie Sha, Jinghui Zhang, Li-Qun Xu*, Jian Li, (corresponding author), Portable Nanopore-Sequencing Technology: Trends in Development and Applications. Frontiers in Microbiology, 2023.

3. Jian Li, Weicheng Liang, Xingyu Li, Pan Gu, Anna Liu, Pin Chen, Qiwei Li, Xueyin Mei, Jing Yang, Jun Liu, Lincao Jiang, Zaozao Chen, Zhongze Gu, OOCDB: A Comprehensive, Systematic, and Real-time Organs-on-a-chip Database, Genomics, Proteomics & Bioinformatics, 2023.

4. Li-Qun Xu, Jing Yang, Weicheng Liang, Jiang Chen, Zepeng Sun, Qiang Zhang, Xinlong Liu, Feng Qiao, Jian Li (corresponding author), LDMD-A database of microbes in human lung disease, Frontiers in Microbiology, 2023.

5. Zepeng Sun, Xinlong Liu, Wei Liu, Jiahui Li, Jing Yang, Feng Qiao, Jianjun Ma, Jingjie Sha, Jian Li, (corresponding author), Li-Qun Xu, AutoNanopre: An Automated Adaptive and Robust Method to Locate Translocation Events in Solid-State Nanopore Current Traces, ACS Omega, 2022.

6. Cai-Li Bi, Qian Cheng, Ling-Yue Yan, Hong-Yan Wu, Qiang Wang, Ping Wang, Lin Cheng, Rui Wang, Lin Yang, Jian Li, Feng Tie, Hao Xie, Ming Fang, A prominent gene activation role for C-terminal binding protein in mediating PcG/trxG proteins through Hox gene regulation, Development, 2022.

7. Lincao Jiang, Qiwei Li, Weicheng Liang, Xuan Du, Yi Yang, Zilin Zhang, Lili Xu, Jing Zhang, Jian Li, (corresponding author), Zaozao Chen, Zhongze Gu, Organ-On-A-Chip Database Revealed-Achieving the Human Avatar in Silicon, Bioengineering, 2022.

8. Yangyang Hao, Liang Lu, Anna Liu, Xue Lin, Li Xiao, Xiaoyue Kong, Kai Li, Fengji Liang, Jianghui Xiong, Lina Qu, Yinghui Li, Jian Li（corresponding author), Integrating bioinformatic strategies in spatial life science research, Briefings in Bioinformatics, 2022.

9. Pin Chen, Xue Lin, Anna Liu, Jian Li（corresponding author), The Brian Research Hotspot Database (BRHD): A Panoramic Database of the Latest Hotspots in Brian Research, Brian Sciences, 2022.

10.Yan Ding, Zining Zhou, Xingyu Li, Chen Zhao, Xiaoxiao Jin, Xiaotao Liu, Yandan Wu, Xueyin Mei, Jian Li（co-corresponding author), Jie Qiu, Chuanlai Shen, Screening and identification of HBV epitopes restricted by multiple prevalent HLA-A allotypes, Frontiers in Immunology, 2022.

11.Xueyin Mei, Xingyu Li, Chen Zhao, Anna Liu，Yan Ding，Chuanlai Shen，Jian Li(corresponding author)，The Use of Molecular Dynamics Simulation Method to Quantitatively Evaluate Quantitatively Evaluate the Affinity between HBV Antigen T Cell Epitope Peptides and HLA-A Molecules，International Journal of Molecular Sciences, 2022.

12.  Jing Yang, Qiang Zhang, Jun Zhang, Yan Ouyang, Zepeng Sun, Xinlong Liu, Feng Qaio, Li-Qun Xu, Yunfei Niu, Jian Li (corresponding author)，Exploring the change of host and microorganism in chronic obstructive pulmonary disease patients based on metagenomic and metatranscriptomic sequencing, Frontiers in Microbiology, 2022.

13.  Xueyin Mei, Pan Gu, Chuanlai Shen, Xue Lin, Jian Li (corresponding author), Computer-based immunoinformatic analysis to predict candidate T cell epitopes for SARS-CoV-2 vaccine design, Frontiers in Immunology, 2022.

14.  Xingyu Li, Lin Xue, Xueyin Mei, Pin Chen, Anna Liu, Weicheng Liang, Shan Chang, Jian Li (corresponding author), HLA3D-an integrated structure-based computational toolkit for immunotherapy, Briefings in Bioinformatics, 2022.

15.  Xue Lin, Yingyinghua, Shuanglin Gu, Li Lv, Xingyu Li, Pin Chen, Peng Dai, Yunyun Hu, Anna Liu, Jian Li (corresponding author), kataegis: an R package for identification and visualization of the genomic localized hypermuation regions using high-throughput sequencing, BMC Genomics, 2021.

16.  Jin, XX; Ding, Y;Sun, SH;Wang, XY;Zhou, ZN;Liu, XT;Li, MM;Chen, X;Shen, AR;Wu, YD;Liu, BC; Zhang, JQ; Jian Li; Yang, Y;Qiu, HB;Shen, CL;He, YX;Zhao, GY Screening HLA-A-restricted T cell epitopes of SARS-CoV-2 and the induction of CD8(+) T cell responses in HLA-A transgenic mice, Cellular & Molecular Immunology, 2021.

17.  Rongrong Guo, Jian Li(co-first author), Chen, CT, Xiao, M, Liao, MH, Hu, YN, Liu, Y, Li, D, Zou, J, Sun, DP, Torre, Zhang, Renjie Chai, Mingliang Tang, Biomimetic 3D bacterial cellulose-graphene foam hybrid scaffold regulates neural stem cell proliferation and differentiation, Colloids and Surfaces B: Biointerfaces, 2021.

18.  Kaiyu Xue, Yunyun Hu, Shuanglin Gu, Chao Wang, Ren Kong, Wei Xie, Jian Li(corresponding author), Using structural analysis to clarify the impact of single nucleotide variants in neurexin/neuroligin revealed in clinical genomic sequencing, Journal of Biomolecular Structure and Dynamics, 2021.

19.  Shanglin Gu, Li Lv, Xue Lin, Xingyu Li, Juncheng Dai, Jianqiong Zhang, Ren Kong, Wei Xie, Jian Li(corresponding author),Using structural analysis to explore the role of hepatitis B virus mutations in immune escape from liver cancer in Chinese, European and American populations, Journal of Biomolecular & Dyanmics, 2020.

20.  Jian Li (Co-corresponding author), Xue Lin, Mingya Wang, Yunyun Hu, Kaiyu Xue, Shuanglin Gu, Li Lv, Saijun Huang, Wei Xie, Potential Role of Genomic Imprinted Genes and Brain Developmental Related Genes in Autism, BMC Medical Genomics, 2020.

21.  Mingliang Tang, Jian Li, Li He, Rongrong Guoa, Xiaoqian Yan, Dan Li, Yuhua Zhang, Menghui Liao, Buwei Shao, Yangnan Hu, Yun Liu, Qilin Tang, Lin Xia, Xing Guo, Renjie Chai, Transcriptomic profiling of neural stem cell differentiation on graphene substrates. Colloids Surf B Biointerfaces. 2019. 

22.  Yuzhi Wang, Xue Lin, Xue Gong, Lele Wu, Jun Zhang, Weiguang Liu, Jian Li, Liming Chen. Atypical GATA transcription factor TRPS1 represses gene expression by recruiting CHD4/NuRD(MTA2) and suppresses cell migration and invasion by repressing TP63 expression. Oncogenesis. 2018.

23.  Yan Liu, Jian Li (Co-first authors), Zhifang Ma, Jun Zhang, Yuzhi Wang, Zhenghong Yu, Xue Lin, Li An, Huilin Zheng, Shuang Yu, Jingzhong Zhang, Zhi Xu, Liming Chen. Oncogenic functions of Protein Kinase D2 in regulating multiple cancer-related pathways and breast cancer. Cancer Medicine, 2019.

24.  Jing Zuo, Jian Li(Co-first author, co-corresponding author), Rongxin Zhang, Longsheng Xu, Hanhan Chen, Xiaohuan Jia, Zhipeng Su, Linhong Zhao, Xing Huang, Wei Xie, Institute Collection and Analysis of Nanobodies (iCAN): a comprehensive database and analysis platform for nanobodies. BMC Genomics, 2017.

25.  Liu Yan, Jian Li (Co-first authors), Jun Zhang, Zhenghong Yu, Shiyi Yu, Lele Wu, Yuzhi Wang, Xue Gong, Chenxi Wu, Xiuxiu Cai, Lin Mo, Mingya Wang, Jun Gu, Liming Chen. Oncogenic protein kinase D3 regulating networks in invasive breast cancer. International Journal of Biological Sciences, 2017.

26.  Yu Xue, Eric-Wubbo Lameijer, Kai Ye, Kunlin Zhang, Suhua Chang, Xiaoyue Wang, Jianmin Wu, Ge Gao, Fangqing Zhao, Jian Li, Chunsheng Han, Shuhua Xu, Jingfa Xiao, Xuerui Yang, Xiaomin Ying, Xuegong Zhang, Wei-Hua Chen, Yun Liu, Zhang Zhang, Kun Huang, Jun Yu. Precision Medicine: What Challenges Are We Facing? Genomics Proteomics Bioinformatics, 2016.

27.  Anders Patrik Gunnarsson, Rikke Christensen, Jian Li, Uffe Birk Jensen. Global gene expression and comparison between multiple populations in the mouse epidermis, Stem Cell Res. 2016.

28.  Xue Lin, Jan Stenvang, Mads Kristoffer Heilskov Rasmussen, Shida Zhu, Guangxia Yang, Kirstine Belling, Claus Lindbjerg Andersen*, Jian Li*, Lars Bolund*, Nils Brünner*. The Potential Role of Alu Y in the Development of Resistance to SN38 (Irinotecan) and Oxaliplatin in Colon Cancer (* corresponding author), BMC Genomics, 2015.