罗玉璇  教授，博士生导师

E-mail: yuxuanluo@seu.edu.cn

办公地点：东南大学江北校区汇川楼D101

个人简介：

2009 年本科毕业于四川大学（生物学基地班），2014 年在北京协和医学院（清华大学医学部） 获得博士学位，2014-2017 年在重庆医科大学附属第二医院从事研究工作，2017-2021 年在美国德克 萨斯大学西南医学中心进行博士后研究，2022 年入职东南大学，聘为东南大学青年首席教授，并入 选国家级青年人才计划。

研究方向：心血管疾病发病机制

心血管疾病是人类健康的“第一杀手”，严重影响着人们的生活质量并威胁人类生命健康，且发 病率逐年增加。目前关于心血管疾病的发病机制尚不完全清楚，本课题组聚焦心血管疾病的发病机 制，围绕引起心肌肥厚和心肌损伤的信号通路和下游转录因子，以及心血管疾病中线粒体功能失常 的分子机制，以小鼠为模式动物，运用生物化学与分子生物学、细胞生物学、生物信息学等方法深 入探究影响心血管功能的关键因素，筛选出药物治疗靶点以及其它治疗或预防策略，为心血管疾病 的精准诊治提供了新思路。

代表性论文： （* 通讯作者; # 第一作者）

1. Xiaoxuan Zhong, Xiang Wei, Yan Xu, Xuehai Zhu, Bo Huo, Xian Guo, Gaoke Feng, Zihao Zhang, Xin  Feng, Zemin Fang, Yuxuan Luo *, Xin Yi * , Ding-Sheng Jiang * . The lysine methyltransferase SMYD2  facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis. Acta Pharmaceutica Sinica B,  2024;14(2):712-728. 

 2. Yuxuan Luo, Nan Jiang, Herman I. May, Xiang Luo, Anwarul Ferdous, Gabriele G. Schiattarella, Guihao  Chen, Qinfeng Li, Chao Li, Beverly A. Rothermel, Dingsheng Jiang, Sergio Lavandero, Thomas G. Gillette,  Joseph A. Hill. Cooperative binding of ETS2 and NFAT link Erk1/2 and calcineurin signaling in the  pathogenesis of cardiac hypertrophy. Circulation. 2021;144:34-51. 

3. Anwarul Ferdous, Sarvjeet Singh, Yuxuan Luo, Md. J. Abedin, Nan Jiang, Cameron E. Perry, Bret M.  Evers, Thomas G. Gillette, Michael Kyba, Maria Trojanowska, Joseph A. Hill. Fli1 Promotes Vascular  Morphogenesis by Regulating Endothelial Potential of Multipotent Myogenic Progenitors. Circulation  Research. 2021;129:949–964. 

 4. Gabriele G. Schiattarella, Francisco Altamirano, Soo Young Kim, Dan Tong, Anwarul Ferdous, Hande  Piristine , Subhajit Dasgupta, Xuliang Wang, Kristin M. French, Elisa Villalobos, Stephen B. Spurgin,  Maayan Waldman, Nan Jiang, Herman I. May, Theodore M. Hill, Yuxuan Luo, Heesoo Yoo, Vlad G. Zaha,  Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill. Xbp1s-FoxO1 axis governs lipid accumulation and  contractile performance in heart failure with preserved ejection fraction. Nature Communications, 2021;  12:1684. 

 5. Anwarul Ferdous, Zhao V. Wang, Yuxuan Luo, Dan L. Li, Xiang Luo, Gabriele G. Schiattarella, Francisco  Altamirano, Herman I. May, Pavan K. Battiprolu, Annie Nguyen, Beverly A. Rothermel,Sergio Lavandero,  Thomas G. Gillette, Joseph A. Hill. FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone  metabolism and hypertrophic growth. Nature Communications, 2020;11:2551.  

6. Yu-Xuan Luo #, Xiaoqiang Tang # , Xi-Zhou An, Xue-Min Xie, Xiao-Feng Chen, Xiang Zhao, De-Long  Hao, Hou-Zao Chen, De-Pei Liu. Sirt4 accelerates Ang II-induced pathological cardiac hypertrophy by  inhibiting manganese superoxide dismutase activity. European Heart Journal, 2017. 38(18): p. 1389-1398. 

 7. Xi Jiang # , Ke-Qiong Deng # , Yu-Xuan Luo #, Ding-Sheng Jiang, Lu Gao, Xiao-Fei Zhang, Peng Zhang,  Guang-Nian Zhao, Xueyong Zhu, Hongliang Li. Tumor Necrosis Factor Receptor–Associated Factor 3 Is a  Positive Regulator of Pathological Cardiac Hypertrophy. Hypertension, 2015. 66(2): p. 356-67.  

8. Yuan Zhang, Jing Xu, Yu-Xuan Luo, Xi-Zhou An, Ran Zhang, Guang Liu, Hongliang Li, Hou-Zao Chen,  De-Pei Liu. Overexpression of Mitofilin in the Mouse Heart Promotes Cardiac Hypertrophy in Response to  Hypertrophic Stimuli. Antioxid Redox Signal, 2014. 21(12): p. 1693-707.  

9. Ding-Sheng Jiang # , Yu-Xuan Luo #, Ran Zhang # , Xiao-Dong Zhang, Hou-Zao Chen, Yan Zhang, Ke Chen,  Shu-Min Zhang, Guo-Chang Fan, Peter P. Liu, De-Pei Liu, Hongliang Li. Interferon Regulatory Factor 9  Protects Against Cardiac Hypertrophy by Targeting Myocardin. Hypertension, 2014. 63(1): p. 119-27.