邢广林   教授，博士生导师

江苏特聘教授，教育部首批海外引才专项获得者

E-mail: guanglinxing@seu.edu.cn

办公室地点：东南大学江北校区汇川楼A409

实验室地点：东南大学江北校区汇川楼A407

个人简介：

博士毕业于东南大学，随后于美国奥古斯塔大学、凯斯西储大学作博士后研究。2022年2月入职东南大学生命科学与技术学院，担任教授。获教育部引才专项、国家自然科学基金面上、江苏特聘教授特别资助、南京市留学人员科技创新等项目支持。

研究方向：

神经系统是动物体内最重要的系统之一，负责调控学习、记忆、运动、情感和思维等多种高级功能。其工作原理是通过神经元之间的突触连接，形成完整的网络以实现信息的接收、加工和传递。人类大脑约包含1000亿个神经元，每个神经元上分布着数千到数万个突触，整个大脑的突触总数达到数万亿。这些突触在神经系统的信息处理过程中发挥着核心作用，几乎所有的大脑功能异常都与突触功能的改变密切相关。

本课题组主要集中于突触形成和神经退行性疾病的发病机制研究。我们利用小鼠等模式生物，结合细胞生物学、分子生物学和电生理等技术，系统地揭示突触形成和成熟的调控机制，以及运动神经元退行性疾病的发病机制及其潜在治疗策略。

代表性论文：

1.        Guanglin Xing, Hongyang Jing, Zheng Yu, Peng Chen, Hongsheng Wang, Wen-Cheng Xiong*, and Lin Mei*. Membraneless condensates by rapsyn phase separation as a platform for neuromuscular junction formation. Neuron, 2021, https://doi.org/10.1016/j.neuron.2021.04.021, Cover Story, Volume 109, Issue 12.

2.        Guanglin Xing, Wen-Cheng Xiong, and Lin Mei*. (2020). Rapsyn as a signaling and scaffolding molecule in NMJ formation and maintenance. Neuroscience Letters, 135013. doi.org/10.1016/j.neulet.2020.135013, Review.

3.        Guanglin Xing#, Hongyang Jing#, Lei Zhang, Yu Cao, Lei Li, Kai Zhao, Zhaoqi Dong, Wenbing Chen, Hongsheng Wang, Rangjuan Cao, Wen-Cheng Xiong, and Lin Mei* (2019). A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome. eLife 2019; 8: e49180 DOI: 10.7554/eLife. 49180.

4.        Guanglin Xing#, Moyi Li#, Yichen Sun, Menglong Rui, Yan Zhuang, Huihui Lv, Junhai Han, Zhengping Jia*, and Wei Xie*. (2018). Neurexin-Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction. eLife 2018; 7: e30457 DOI: 10.7554/eLife.30457.

5.        Guanglin Xing#, Guangming Gan#, Dandan Chen, Mingkuan Sun, Jukang Yi, Huihui Lv, unhai Han, and Wei Xie*. (2014). Drosophila neuroligin3 regulates neuromuscular junction development and synaptic differentiation. The Journal of Biological Chemistry 289, 31867-31877; a paper of the week.

6.        Zhibing Tan#, Heath L. Robinson#, Dong-Min Yin, Yu Liu, Fang Liu, Hongsheng Wang, Thiri W. Lin, Guanglin Xing, Lin Gan, Wen-Cheng Xiong, and Lin Mei* (2018). Dynamic ErbB4 Activity in Hippocampal-Prefrontal Synchrony and Top-Down Attention in Rodents. Neuron 98, 380-393 e384.

7.        Lei Li#, Yu Cao#, Haitao Wu, Xinchun Ye, Zhihui Zhu, Guanglin Xing, Chenyong Shen, Arnab Barik, Bin Zhang, Xiaoling Xie, Wenbo Zhi, Lin Gan, Huabo Su, Wen-Cheng Xiong, and Lin Mei*. (2016). Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation. Neuron 92, 1007-1019.

8.         Mingkuan Sun, Guanglin Xing, Liudi Yuan, Guangmin Gan, David Knight, Sheila lrene With, He Cui, Han, Junhai Han, Xiankun Zeng, Ming Fang, Gabeielle L. Boulianne, and Wei Xie*. (2011). Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction. The Journal of Neuroscience, 31, 687-699.