柴人杰课题组

发布者：许峰发布时间：2019-02-27浏览次数：10957


课题组长：柴人杰，东南大学生命科学研究院

研究领域：神经干细胞和内耳干细胞的转录调控机制，听觉神经元和毛细胞再生

地址：南京市玄武区四牌楼2号，东南大学李文正楼北231室，210096

电话： 18805193999

Email： Renjiec@seu.edu.cn



研究组长简介：

柴人杰，1982年11月出生，东南大学生命科学研究院三级教授，博士生导师，院长助理，支部书记；国家优青；现任中国生物物理学会听觉、言语与交流分会副会长；中国生理学会干细胞与神经分会秘书长，常务理事；国际耳内科医师协会执委（Executive board member）；中国听力医学发展基金会专家指导委员会常务委员，听觉基础研究专委会副主委；中国医促会耳内科分会听觉基础研究学组组长；中国老年医学学会耳科学分会常务委员；常务理事和生物医药专委会副主委，秘书长；江苏省发育生物学会常务理事，青年委员会主委和听觉科学专委会主委；江苏省双创联合会常务理事和生物医药专委会副秘书长；中国研究型医学会神经再生与修复专委会委员；江苏省神经生物学会理事；美国耳鼻喉研究学会会员；国际干细胞研究学会会员，江苏省防聋治聋技术指导专家组委员。先后入选包括国家优秀青年科学基金，教育部霍英东教育基金会优秀青年教师基金，江苏省杰出青年基金，江苏省双创人才，江苏省双创团队，江苏省333工程人才，江苏省六大人才高峰高层次人才等人才计划；先后作为课题负责人主持科技部国家重点研发计划干细胞及转化研究重点专项和科技部青年973计划，主持中国科学院“器官重建与制造”A类战略性先导科技专项，军委科技委军事脑科学项目，国家自然科学基金委面上项目，人力资源和社会保障部留学人员科技活动重点项目，教育部留学人员项目，全球二十强药企德国Boehringer Ingelheim 公司的500万元的Faculty Research Award和瑞士Novartis公司70万元Faculty Research Award等15项课题。相关工作发表在Advanced Materials, Nature communications, Sciences Advances, Advanced Functional Materials,3篇PNAS，Autophagy，Biomaterials, ACS Applied Materials & Interfaces, Antioxidants & Redox Signaling, 2篇Development，Drug Delivery，Cell Death & Disease，Molecular Neurobiology等有国际影响力的学术期刊上，近5年发表SCI论文72篇（总影响因子481.8）；其中第一和通讯作者论文47篇（总影响因子292.5，其中IF>10分5篇）；作为主编出版专著人工听觉技术概要，研究成果被国际科学网站和权威期刊多次正面评价和引用；另有国际会议大会发言6次，国际会议论文21篇，作为大会主席参与举办了三届中国听觉科学大会（第1,3,4届），作为分论坛主席主持了一届国际耳内科医师学会年会听觉异常与平衡障碍分论坛（第19届），主持了两届中国生物物理学会年会听觉研究分论坛（第16,17届），主持了一届中国神经科学学会年会听觉研究分论坛（第12届）。现任SCI期刊American Journal of Stem Cells(AJSC) 执行主编 (Executive Editor-in-Chief)，American Journal of Translational Research（AJTR），Hearing Research，Frontiers of Medicine，Global Journal of Otolaryngology，Engineering和Journal of Otorhinolaryngology, Hearing and Balance Medicine（OHBM）期刊编委(Editorial Board Member)，Neural Plasticity 期刊Lead Guest Editor。


研究内容：长期致力于神经元和内耳毛细胞的再生和保护以及神经干细胞和内耳干细胞的转录调控机制的研究。主要研究内容包括：1.系统的研究了多种信号通路对于内耳干细胞和神经干细胞增殖和分化的转录调控机制；2.结合多基因协同调控，生物材料和电刺激，磁刺激等物理调控因素有效促进神经元和毛细胞的再生和听觉功能的部分重建；3通过调控自噬，线粒体功能和氧化应激有效的保护了噪音和药物导致的毛细胞损伤和听力损失。



代表性论著

专著：

  1. 柴人杰（主编），陈峰，陈杰，戴艳红，高下（主编），陆玲，麻晓峰，王俊国，钱晓云，杨烨，俞晨杰，张莎莎，周函，朱光洁，人工听觉技术概要，南京大学出版社, 352千字，ISBN 978-7-305-17890-0，2016


代表性期刊论文：

  1. Yan Liu#, Jieyu Qi#, Xin Chen#, Mingliang Tang#, Cenfeng Chu, Weijie Zhu, Hui Li, Cuiping Tian, Guang Yang, Chao Zhong, Zhang Ying, Guangjian Ni, Shuijin He*, Renjie Chai*（并列通讯作者）, Guisheng Zhong*. Critical role of spectrin in hearing development and deafness. Science Advances, In Press, 2019(IF: 11.514)

  2. Zhongmin Liu#, Mingliang Tang#, Jinping Zhao, Renjie Chai*（并列通讯作者）, Jiuhong Kang*. Looking into the Future: Towards Advanced Three-Dimensional Biomaterials for Stem Cell-Based Regenerative Medicine. Advanced Materials, 1705388, 2018(IF:21.950)

  1. Luoran Shang, Yunru Yu, Wei Gao, Yuetong Wang, Liangliang Qu, Ze Zhao, Renjie Chai*（并列通讯作者）, Yuanjin Zhao*. Bio-inspired Anisotropic Wettability Surface from Dynamic Ferrofluid Assembled Templates. Advanced Functional Materials, 1705802, 2018(IF:13.325)

  2. Sana Shaikh, Fawad Rehman, Tianyu Du, Hui Jiang, Lihong Yin, Xuemei Wang*, Renjie Chai*（并列通讯作者）. Real-time Multimodal Bioimaging of Cancer Cells and Exosomes through Biosynthesized Iridium and Iron Nanoclusters.ACS Applied Materials & Interfaces, doi: 10.1021/acsami.8b08975, 2018 (IF:8.097) 

  3. Wenwen Liu, Xiaochen Xu, Zhaomin Fan, Gaoying Sun, Yuechen Han, Daogong Zhang, Lei Xu, Mingming Wang, Xue Wang, Shasha Zhang, Mingliang Tang, Jianfeng Li, Renjie Chai*（并列通讯作者）, Haibo Wang*.Wnt signaling activates TIGAR and protects against cisplatin-induced spiral ganglion neuron damage in the mouse cochlea.Antioxidants & Redox Signaling, doi: 10.1089/ars.2017.7288, 2018 (IF:6.530)

  4. Wenqing Yan#, Wenwen Liu#, Jieyu Qi, Qiaojun Fang, Zhaomin Fan, Gaoying Sun, Yuechen Han, Daogong Zhang, Lei Xu, Mingming Wang, Jianfeng Li, Fangyi Chen, Dong Liu*, Renjie Chai*（并列通讯作者）, Haibo Wang*. A Three-Dimensional Culture System with Matrigel Promotes Purified Spiral Ganglion Neuron Survival and Function In Vitro.Molecular Neurobiology, 55(3):2070-2084., 2018(IF:6.19)

  5. Zuhong He#, Lingna Guo#, Yilai Shu#, Qiaojun Fang, Han Zhou, Yongze Liu, Dingding Liu, Ling Lu, Xiaoli Zhang, Xiaoqiong Ding, Dong Liu, Mingliang Tang, Weijia Kong, Suhua Sha, Huawei Li*, Xia Gao*, Renjie Chai*（并列通讯作者）. Autophagy protects auditory hair cells against neomycin-induced damage. Autophagy, 2:1-21, 2017(IF:11.100)

  6. Shasha Zhang, Yuan Zhang, Pengfei Yu, Yao Hu, Han Zhou, Lingna Guo, Xiaochen Xu, Xiaocheng Zhu, Muhammad Waqas, Jieyu Qi, Xiaoli Zhang, Xiaoyun Qian, Fangyi Chen, Mingliang Tang, Yan Liu, Haibo Shi*, Xia Gao*, Renjie Chai*（并列通讯作者）. Characterization of Lgr5+ progenitor cell transcriptomes after neomycin injury in the neonatal mouse cochleae.Frontiers in Molecular Neuroscience, 10:213, 2017(IF:5.076)

  7. Xiaoling Lu#, Shan Sun#, Jieyu Qi, Wenyan Li, Liman Liu, Yanping Zhang, Yan Chen, Shasha Zhang, Lei Wang, Dengshun Miao, Renjie Chai*（并列通讯作者）, Huawei Li*. Bmi1 regulates the proliferation of cochlear supporting cells via the canonical Wnt signaling pathway. Molecular Neurobiology, 54(2):1326-1339, 2017(IF:6.19)

  8. Rongrong Guo#, Shasha Zhang#, Miao Xiao, Fuping Qian, Zuhong He, Dan Li, Xiaoli Zhang,  Huawei Li, Xiaowei Yang, Ming Wang, Renjie Chai*（并列通讯作者）, Mingliang Tang*.Accelerating bioelectric functional development of neural stem cells by graphene coupling: Implications for neural interfacing with conductive materials. Biomaterials, 106:193-204. 2016(IF:8.402)

  9. Liman Liu#, Yan Chen#, Jieyu Qi Yanping Zhang, Yingzi He, Wenli Ni, Wen Li, Shasha Zhang, Shan Sun, Makoto Taketo, Lei Wang, Renjie Chai*（并列通讯作者）, Huawei Li*. Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea.Cell Death & Disease, 10;7:e2136, 2016(IF:5.965)

  10. Tian Wang#, Renjie Chai#（并列第一作者）, Grace Kim, Nicole Pham, Lina Jansson, Duc-Huy Nguyen, Bryan Kuo, Lindsey May, Jian Zuo, Lisa Cunningham, Alan Cheng*. Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatalmouse utricle. Nature Communications, 7;6:6613, 2015(IF:11.47)

  11. Brandon Cox#, Renjie Chai#（并列第一作者）, Anne Lenoir, Zhiyong Liu, LingLi Zhang, Duc-Huy Nguyen,Kavita Chalasani, Katherine Steigelman Jie Fang, Alan Cheng*, Jian Zuo*. Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo.Development, 141,816-29, 2014(IF:6.462)

  12. Taha Jan#, Renjie Chai#（并列第一作者）, Zahra Sayyid, Renée Amerongen, Anping Xia, Tian Wang,Saku Sinkkonen, Yi Zeng, Jared Levin, Stefan Heller, Roel Nusse*, Alan Cheng*.  Tympanic border cells are Wnt-responsive and act as progenitors for postnatal mouse cochlear cells. Development,140, 1196-1206, 2013(IF:6.273)

  13. Renjie Chai#, Bryan Kuo#, Tian Wang, Eric Liaw, Anping Xia, Taha Jana, Zhiyong Liu, Makoto M. Taketo, John Oghalai, Roeland Nusse, Jian Zuo*, Alan Cheng*. Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Proc Natl Acad Sci U S A, 109(21):8167-72, 2012 (IF:9.737)