王苏课题组

王苏 教授，博士生导师

电话： 025-83790967

E-mail: wangsu@seu.edu.cn

办公地点： 南京市四牌楼2号，李文正楼北楼217室

个人简介

2010于北京大学获得学士学位，2015于美国堪萨斯大学医学中心获得博士学位，并在美国Stowers医学研究所担任博士生研究员。2017年加入东南大学生命科学研究院担任研究员，分别入选中组部海外高层次人才“青年项目”，江苏省特聘教授，江苏省双创人才，江苏省“六大人才高峰”高层次人才。

研究方向：神经干细胞功能和中枢神经系统发育调控机制

神经干细胞因其自我更新及分化的潜力，成为未来临床治疗多种神经退行性疾病的重要潜在治疗方法。如何在活体中精确安全地调控神经干细胞的命运决定是当今的主要研究热点之一，也是制约其临床应用的主要瓶颈之一。本课题组通过多种模式生物，研究内部命运决定因子和外部微环境对神经干细胞功能和中枢神经系统发育的调控机制。

代表文献：

1. Mengzhu Ou^#, Su Wang^#, Mingkuan Sun, Jinsong An, Huihui Lv, Xiankun Zeng, Steven X. Hou*, Wei Xie*.: The PDZ-GEF Gef26 regulates synapse development and function via FasII and Rap1 at the Drosophila neuromuscular junction. Experimental Cell Research. 2019 Jan 15; 374(2):342-352. doi: 10.1016/j.yexcr.2018.12.008.

2. Tingting Gao^#, Xin Zhao^#, Chenchen Liu^#, Binbin Shao^#, Xi Zhang, Kai Li, Jinyang Cai, Su Wang*, Xiaoyan Huang*.: Somatic Angiotensin I-Converting Enzyme Regulates Self-Renewal of Mouse Spermatogonial Stem Cells Through the Mitogen-Activated Protein Kinase Signaling Pathway. Stem Cells and Development. 2018 Aug 1;27(15):1021-1032. doi: 10.1089/scd.2017.0287.

3. Xing Ma^#, Xiujuan Zhu, Yingying Han, Benjamin Story, Trieu Do, Xiaoqing Song, Su Wang, Ying Zhang, Marco Blanchette, Madelaine Gogol, Kate Hall, Allison Peak, Perera Anoja, Ting Xie*.: Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms. Developmental Cell. 2017 Apr 24; 41(2):157-169. e5. doi: 10.1016/j.devcel.2017.03.023.

4. Tinglin Lu^#, Su Wang^#, Yuan Gao, Ying Mao, Zhihao Yang, Luping Liu, Xiaoqing Song, Jianquan Ni, Ting Xie*.: COP9-Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila ovary. Development. 2015 Dec 15;142(24):4242-52.

5. Su Wang^#, Yuan Gao, Xiaoqing Song, Xing Ma, Xiujuan Zhu, Ying Mao, Zhihao Yang, Jianquan Ni, Hua Li, Kathryn E Malanowski, Perera Anoja, Jungeun Park, Jeff Haug, Ting Xie*.: Wnt Signaling-Mediated Redox Regulation Maintains the Germline Stem Cell Differentiation Niche. eLife. 2015 Oct 9; 4. doi: 10.7554/eLife.08174

6. Lei Pan^#, Su Wang^#, Tinglin Lu^#, Changjiang Weng, Xiaoqing Song, Joseph K. Park, Jin Sun, Zhi-HaoYang, JunjingYu, Hong Tang, Dennis M. McKearin, Daniel A. Chamovitz, Jianquan Ni，Ting Xie*.: Protein competition switches the function of COP9 from self-renewal to differentiation. Nature. 2014 Oct 9; 514(7521):233-6.

7. Xing Ma^#, Su Wang, Trieu Do, Xiaoqing Song, Mayu Inaba, Yoshiya Nishimoto, Lu-ping Liu,Yuan Gao, Ying Mao, Hui Li, William McDowell, Jungeun Park, Kate Malanowski, Allison Peak, Anoja Perera, Hua Li, Karin Gaudenz, Jeff Haug, Yukiko Yamashita, Haifan Lin, Jian-quan Ni, Ting Xie*.: Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary. PLoS One. 2014 Mar 21; 9(3):e90267.

8. Xiaoxi Wang^#, Lei Pan^#, Su Wang^#, Jian Zhou, William McDowell, Jungeun Park, Jeff Haug, Karen Staehling, Hong Tang, Ting Xie*.: Histone H3K9 trimethylase Eggless controls germline stem cell maintenance and differentiation. PLoS Genet. 2011 Dec 22; 7(12):e1002426.

9. Daniel Kirilly^#, Su Wang^#, Ting Xie*.: Self-maintained escort cells form a germline stem cell differentiation niche. Development. 2011 Dec; 138(23):5087-97.

10. Shuyi Chen^#, Su Wang, Ting Xie*.: Restricting self-renewal signals within the stem cell niche: multiple levels of control. Curr Opin Genet Dev. 2011 Dec; 21(6):684-9.