张子超 研究员 博士生导师
Email：zhangzc@seu.edu.cn
办公地点：东南大学江北校区汇川楼A411
个人简介
1998-2002年，南京大学，生物化学专业，学士
2002-2005年，南京大学，生物化学与分子生物学，硕士
2005-2011年，美国得克萨斯州大学西南医学中心，细胞调控专业，博士
2011-2012年，美国得克萨斯州大学西南医学中心，药理系，博士后
2012-2022年，东南大学，生命科学研究院，副教授
2022年至今，东南大学生命科学与技术学院，研究员
研究方向
儿童智力发育迟缓和老年人群中的神经退行性疾病是常见多发的神经系统疾病，目前人们对其复杂的发病机理知之甚少，缺乏有效的治疗手段，是生物医学领域里未解的难题。对神经发育，突触形成和维持，神经递质的传递和神经环路形成过程中关键分子及分子事件的研究是解开难题的核心。我们主要运用生物化学与分子生物学，细胞生物学，结构生物学，生物信息学和遗传学等方法与手段，通过对细胞内蛋白质的表达调控，蛋白质之间的相互作用，蛋白质和RNA等生物大分子在细胞内的转运以及相应细胞生理生化功能的研究，来揭示神经发育与退化过程的分子机制，探讨智力发育迟缓和神经退行性性疾病的发病机理，寻找新的治疗手段。
代表性论文
1. Liu, X., Xie, H., Liu, W., Zuo, J., Li, S.，..., Zhang, Z.C.*et al. (2024). Dynamic regulation of alternative polyadenylation by PQBP1 during neurogenesis. Cell reports 43, 114525. 10.1016/j.celrep.2024.114525.
2. Zhang, Z., Wang, Y., Zhao, J., Han, S., Zhang, Z.C.*, and Tian, Y*. (2023). High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster. J Vis Exp. 10.3791/65787.
3. Liu, W.#, Xie, H.#, Liu, X.#, Xu, S., Cheng, S., Wang, Z., Xie, T., Zhang, Z.C*., and Han, J*. (2023). PQBP1 regulates striatum development through balancing striatal progenitor proliferation and differentiation. Cell reports 42, 112277. 10.1016/j.celrep.2023.112277.
4. Cheng, S., Liu, X., Yuan, L., Wang, N., Zhang, Z.C.*, and Han, J*. (2023). The role of PQBP1 in neural development and function. Biochem Soc Trans 51, 363-372. 10.1042/bst20220920.
5. Lopez-Martín, S., Albert, J., Peña Vila-Belda, M.D.M., Liu, X., Zhang, Z.C., Han, J., Jiménez de Domingo, A., Fernández-Mayoralas, D.M., Fernández-Perrone, A.L., Calleja-Pérez, B., et al. (2022). A mild clinical and neuropsychological phenotype of Renpenning syndrome: A new case report with a maternally inherited PQBP1 missense mutation. Appl Neuropsychol Child 11, 921-927. 10.1080/21622965.2021.1970551.
6. Wang, J.F., Han, J.H., and Zhang, Z.C.* (2021). Behavioral analyses in mouse models of autism spectrum disorders. Yi Chuan 43, 501-519. 10.16288/j.yczz.20-391.
7. Shen, Y.#, Zhang, Z.C.#*, Cheng, S.#, Liu, A., Zuo, J., Xia, S., Liu, X., Liu, W., Jia, Z., Xie, W., and Han, J*. (2021). PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation. Mol Cell 81, 1425-1438.e1410. 10.1016/j.molcel.2021.01.032.
8. Shen, Y., Liu, W., Zuo, J., Han, J., and Zhang, Z.C.* (2021). Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes. STAR Protoc 2, 100616. 10.1016/j.xpro.2021.100616.
9. Shen, Y., Han, J., and Zhang, Z.C.* (2021). Novel regulation of the eEF2K/eEF2 pathway: prospects of 'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'. J Mol Cell Biol 13, 392-394. 10.1093/jmcb/mjab017.
10. Jin, X., Tian, Y., Zhang, Z.C., Gu, P., Liu, C., and Han, J. (2021). A subset of DN1p neurons integrates thermosensory inputs to promote wakefulness via CNMa signaling. Curr Biol 31, 2075-2087.e2076. 10.1016/j.cub.2021.02.048.
11. Cheng, S., Shen, Y., Zhang, Z.C.*, and Han, J*. (2021). Protocol for interfering peptide injection into adult mouse hippocampus and spatial memory testing. STAR Protoc 2, 100679. 10.1016/j.xpro.2021.100679.
12. Zhang, Z.C., and Han, J*. (2020). The First National Prevalence of Autism Spectrum Disorder in China. Neurosci Bull 36, 959-960. 10.1007/s12264-020-00571-x.
13. Liu, X., Dou, L.X., Han, J., and Zhang, Z.C.* (2020). The Renpenning syndrome-associated protein PQBP1 facilitates the nuclear import of splicing factor TXNL4A through the karyopherin β2 receptor. The Journal of biological chemistry 295, 4093-4100. 10.1074/jbc.RA119.012214.
14. Gu, Q., Wu, J., Tian, Y., Cheng, S., Zhang, Z.C.*, and Han, J*. (2020). Gαq splice variants mediate phototransduction, rhodopsin synthesis, and retinal integrity in Drosophila. The Journal of biological chemistry 295, 5554-5563. 10.1074/jbc.RA120.012764.
15. Mu, Y., Tian, Y., Zhang, Z.C.*, and Han, J*. (2019). Metallophosphoesterase regulates light-induced rhodopsin endocytosis by promoting an association between arrestin and the adaptor protein AP2. The Journal of biological chemistry 294, 12892-12900. 10.1074/jbc.RA119.009602.
16. Guo, L., Kim, H.J., Wang, H., Monaghan, J., Freyermuth, F., Sung, J.C., O'Donovan, K., Fare, C.M., Diaz, Z., Singh, N., et al. (2018). Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell 173, 677-692.e620. 10.1016/j.cell.2018.03.002.
17. Zhang, X.Y., Qi, J., Shen, Y.Q., Liu, X., Liu, A., Zhou, Z., Han, J., and Zhang, Z.C.* (2017). Mutations of PQBP1 in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction. Hum Mol Genet 26, 955-968. 10.1093/hmg/ddx010.
18. Tian, Y., Zhang, Z.C., and Han, J*. (2017). Drosophila Studies on Autism Spectrum Disorders. Neurosci Bull 33, 737-746. 10.1007/s12264-017-0166-6.
19. Li, Q., Li, Y., Wang, X., Qi, J., Jin, X., Tong, H., Zhou, Z., Zhang, Z.C., and Han, J*. (2017). Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABA(A) Receptor. Curr Biol 27, 3616-3625.e3615. 10.1016/j.cub.2017.10.052.
20. Tong, H., Li, Q., Zhang, Z.C., Li, Y., and Han, J*. (2016). Neurexin regulates nighttime sleep by modulating synaptic transmission. Sci Rep 6, 38246. 10.1038/srep38246.
21. Wei, J.H.*, Zhang, Z.C., Wynn, R.M., and Seemann, J*. (2015). GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules. Cell 162, 287-299. 10.1016/j.cell.2015.06.014.
22. Wan, D.#, Zhang, Z.C.#, Zhang, X., Li, Q., and Han, J*. (2015). X chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs. Hum Mol Genet 24, 4599-4614. 10.1093/hmg/ddv191.
23. Tian, Y., Li, T., Sun, M., Wan, D., Li, Q., Li, P., Zhang, Z.C., Han, J.*, and Xie, W*. (2013). Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturation. Neuron 77, 311-322. 10.1016/j.neuron.2012.11.012.
24. Li, Y., Zhou, Z., Zhang, X., Tong, H., Li, P., Zhang, Z.C., Jia, Z., Xie, W., and Han, J*. (2013). Drosophila neuroligin 4 regulates sleep through modulating GABA transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience 33, 15545-15554. 10.1523/jneurosci.0819-13.2013.
