李默怡

发布者:系统管理员发布时间:2019-08-23浏览次数:19

   

            李默怡     副教授、硕士生导师

            电  话

             Email: limoyi@seu.edu.cn

            办公地点:李文正楼南204



个人简介:

19969月 — 20006月    学士, 微生物专业,华中农业大学

20009月 — 20036月    硕士, 生化工程专业,华中科技大学

20038月 — 20085月    博士, 植物病理专业,佛罗里达大学

20091月 — 20137月    博士后,佛罗里达大学

20141月 — 20162月    博士后,东南大学生命科学与技术学院

20162月至今                   副教授,东南大学生命科学与技术学院


研究方向:

1. 神经发育与退行性疾病的分子机理

2. 环路发育及功能的遗传控制机制


近期代表性论文:

  1. Xing G*, Li M* (co-first author), Sun Y, Rui M, Zhuang Y, Lv H, Han J, Jia Z, Xie W.  Neurexin-Neuroligin 1 regulates synaptic morphology and function via the WAVE regulatory complex in Drosophila neuromuscular junction. (2018) eLife;7: e30457

  2. Tu R, Qian J, Rui M, Tao N, Sun M, Zhuang Y, Lv H, Han J, Li M, and Xie W. Proteolytic cleavage is required for functional Neuroligin 2 maturation and trafficking in Drosophila. (2017) J Mol. Cell Biol. 9: 231-242

  3. Liang X, Liberti D, Li M, Kim YT, Hutchens A, Wilson R, Rollins JA. Oxaloacetate acetylhydrolase gene mutants of Sclerotinia sclerotiorum do not accumulate oxalic acid, but do produce limited lesions on host plants. (2015) Mol. Plant Pathol. 16: 559-571.

  4. Batra R, Charizanis K, Manchanda M, Mohan A, Li M, Finn D J, Goodwin M, Zhang C, Sobczak K, Thornton C A., and Swanson MS. Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA Mediated Disease. (2014) Mol. Cell. 56: 311-322

  5. Lee KY*, Li M* (co-first author), Manchanda M, Batra R, Charizanis K, Mohan A, Warren SA, Finn D, Hong H, Ashraf H, Kasahara H, Chamberlain CM, Ranum LPW and Swanson MS. Compound loss of muscleblind-like function in myotonic dystrophy. (2013) EMBO Mol. Med. 5:1887-1900

  6. Poulos MG, Batra R, Li M, Yuan Y, Zhang C, Darnell RB and Swanson MS. Progressive impairment of muscle regeneration in muscleblind-like 3 Isoform knockout mice. (2013) Hum. Mol. Genet. 22: 3547-3558

  7. Warren SA, Briggs LE, Zeng H, Chuang J, Chang Eileen, Terada R, Li M, Swanson MS, Wood CE,  Spinale FG, Maupine-Furlow J, McMullen JR, Moss R, Kasahara H. Myosin light chain phosphorylation is critical for adaptation to cardiac stress. (2012) Circulation. 126: 2575-2588  

  8. Li M., Liang X., and Rollins J.A. Sclerotinia sclerotiorum gamma-glutamyl transpeptidase (Ss-Ggt1) is required for regulating glutathione accumulation and proper development of sclerotia and compound appressoria. (2012) Mol. Plant Microbe In. 25: 412-420

  9. Li M. and Rollins J.A. The development-specific ssp1 and ssp2 genes of Sclerotinia sclerotiorum encode lectins with distinct yet compensatory regulation. (2010) Fungal Genet. Biol. 47: 531-538

  10. Li M. and Rollins J.A. The development-specific protein (Ssp1) from Sclerotinia sclerotiorum is encoded by a novel gene expressed exclusively in sclerotium tissues. (2009) Mycologia. 101: 34-43