方海同

发布者:系统管理员发布时间:2019-08-23浏览次数:25


    方海同     副教授、硕士生导师

    电  话:                    

     Email:: 101012396@seu.edu.cn

    办公地点:东南大学四牌楼校区李文正楼北233



个人简介:

19989月 — 20027月    学士, 生物化学专业,安徽大学

20059月 — 20086月    硕士, 生物化学与分子生物学专业,中国科学技术大学

20089月 — 20127月    博士, 细胞生物学专业,中国科学院动物研究所

20128月 — 20185月    博士后,新加坡分子与细胞生物学研究所

201811月至今                  副教授, 东南大学生命科学与技术学院


研究方向:

1.干细胞命运决定

2. 表观遗传学



近期代表性论文:

1. Fang HT, El Farran CA, Xing QR, Li P, Cheng H, Tushar W, Xu J, Zhang LF, Li H, Lim B, Loh YH. (2018) Global H3.3 dynamics defines its bimodal role in cell fate transition. Nature Communications. Apr 18;9:1537

2. Mzoughi S, Zhang JX, Hequet D, Teo SX, FangHT, Xing QR, Bezzi M, Ong SL, Shin ME, Wollmann H, Wong E, Al-Haddawi M, Stewart C, Tergaonkar V, Dunn NR, Loh YH, Messerschmidt DM and Guccione E.(2017) PRDM15 safeguards naïve pluripotency by transcriptionally regulating WNT and MAPK/ERK signaling. Nature Genetics. Sep;49(9):1354-1363.

3. Cheng H, Ang YK, El Farran CA, Li P, Fang HT, Liu Tongming, Kong SL, Chin LZ, Ling WY, Lim KH, Li H, Huber T , Loh M, Loh YH, Lim B.(2016) Reprogramming Mouse Fibroblasts into EngraftableMyeloerythroid and Lymphoid Progenitors: Induction and Underlying Mechanisms. Nature Communications. Nov 21;7:13396.

4. Yang BX*, El Farran CA*, Guo HC*, Yu T*, Fang HT, Wang HF, Schlesinger S, Seah YF, Goh GY, Neo SP, Li Y, Lorincz MC, Tergaonkar V, Lim TM, Chen L, Gunaratne J, Collins JJ, Goff SP, Daley GQ, Li H, Bard FA, Loh YH. (2015) Systematic identification of factors for provirus silencing in embryonic stem cells. Cell. Sep; 163(1): 230-245.

5. Fang HT, Zhang B (Co-author), Pan XF, Gao L, Zhen T, Zhao HX, Ma L, Xie J, Liu Z, Yu XJ, Cheng X, Feng TT, Zhang FX, Yang Y, Hu ZG, Sheng GQ, Chen YL, Chen SJ, Chen Z, Zhou GB.(2012) Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor- suppressing fragments in leukemia cells. PNAS. Feb; 109(7): 2521-2526.

6. Zhou GS, Hu Z, Fang HT, Zhang FX, Pan XF, Chen XQ, Hu AM, Xu L, Zhou GB. (2011) Biologic activity of triptolide in t(8;21) acute myeloid leukemia cells. Leukemia Research. Feb; 35(2): 214-218.