李健

发布者:许峰发布时间:2019-07-24浏览次数:3980

李健

博士、教授、博士生导师


电话:13052881142

Email: jianli2014@seu.edu.cn

办公地点:四牌楼校区五五楼312

江苏省生物信息学专委会委员,副秘书长,江苏省高性能计算专委会委员,中国人工智能学会生物信息学与合成生命专委会委员,中国遗传学会高级会员


个人简介:

19969月至20016月,就读于东南大学,获临床医学学士学位

20017月至20033月,在中科院遗传所进行课题研究

20047月至200811月,就读于丹麦奥胡斯大学,获医学博士学位

200811月至20147月,奥胡斯大学研究助理、博士后、主要研究员

20147月至20207月,东南大学生命科学与技术学院,副研究员

20208月至今,东南大学生命科学与技术学院,教授



研究方向:

生物信息学及系统生物学。主要从事基因组学,测序技术研发;使用高性能计算、深度学习与基因组学研究复杂疾病及健康问题。


近期代表性论文:

  1. Jian Li, Xue Lin, Mingya Wang, Yunyun Hu, Kaiyu Xue, Shuanglin Gu, Li Lv, Saijun Huang, Wei Xie, Potential Role of Genomic Imprinted Genes and Brain Developmental Related Genes in Autism, BMC Medical Genomics, 2020, Mar 26;13(1):54.

  2. Mingliang Tang, Jian Li, Li He, Rongrong Guoa, Xiaoqian Yan, Dan Li, Yuhua Zhang, Menghui Liao, Buwei Shao, Yangnan Hu, Yun Liu, Qilin Tang, Lin Xia, Xing Guo, Renjie Chai, Transcriptomic profiling of neural stem cell differentiation on graphene substrates. Colloids Surf B Biointerfaces. 2019 Jun 25;182:110324. doi: 10.1016/j.colsurfb.2019.06.054. 

  3. Yuzhi Wang, Xue Lin, Xue Gong, Lele Wu, Jun Zhang, Weiguang Liu, Jian Li, Liming Chen. Atypical GATA transcription factor TRPS1 represses gene expression by recruiting CHD4/NuRD(MTA2) and suppresses cell migration and invasion by repressing TP63 expression. Oncogenesis. 2018 Dec 19;7(12):96. doi: 10.1038/s41389-018-0108-9.

  4. Yan Liu, Jian Li (Co-first authors), Zhifang Ma, Jun Zhang, Yuzhi Wang, Zhenghong Yu, Xue Lin, Li An, Huilin Zheng, Shuang Yu, Jingzhong Zhang, Zhi Xu, Liming Chen. Oncogenic functions of Protein Kinase D2 in regulating multiple cancer-related pathways and breast cancer. Cancer Medicine, 2019, 8:729–741.

  5.  Jing Zuo, Jian Li(Co-first author, co-corresponding author), Rongxin Zhang, Longsheng Xu, Hanhan Chen, Xiaohuan Jia, Zhipeng Su, Linhong Zhao, Xing Huang, Wei Xie, Institute Collection and Analysis of Nanobodies (iCAN): a comprehensive database and analysis platform for nanobodies. BMC Genomics (2017), 18(1):797. doi: 10.1186/s12864-017-4204-6.

  6. Liu Yan, Jian Li(Co-first authors), Jun Zhang, Zhenghong Yu, Shiyi Yu, Lele Wu, Yuzhi Wang, Xue Gong, Chenxi Wu, Xiuxiu Cai, Lin Mo, Mingya Wang, Jun Gu, Liming Chen. Oncogenic protein kinase D3 regulating networks in invasive breast cancer. International Journal of Biological Sciences, 2017, 13(6): 748-758.

  7. Yu Xue, Eric-Wubbo Lameijer, Kai Ye, Kunlin Zhang, Suhua Chang, Xiaoyue Wang, Jianmin Wu, Ge Gao, Fangqing Zhao, Jian Li, Chunsheng Han, Shuhua Xu, Jingfa Xiao, Xuerui Yang, Xiaomin Ying, Xuegong Zhang, Wei-Hua Chen, Yun Liu, Zhang Zhang, Kun Huang, Jun Yu. Precision Medicine: What Challenges Are We Facing? Genomics Proteomics Bioinformatics 14 (2016) 253–261.

  8. Anders Patrik Gunnarsson, Rikke Christensen, Jian Li, Uffe Birk Jensen. Global gene expression and comparison between multiple populations in the mouse epidermis, Stem Cell Res. 2016 Jul; 17(1):191-202.

  9. Xue Lin, Jan Stenvang, Mads Kristoffer Heilskov Rasmussen, Shida Zhu, Guangxia Yang, Kirstine Belling, Claus Lindbjerg Andersen*, Jian Li*, Lars Bolund*, Nils Brünner*. The Potential Role of Alu Y in the Development of Resistance to SN38 (Irinotecan) and Oxaliplatin in Colon Cancer (* corresponding author), BMC Genomics, 2015, 16:404.