韩俊海

个人简介：  

 1995年9月-1999年月     南京大学，生物化学专业，本科；

 1999年9月-2004年7月    南京大学，分子生物学与生物化学专业，硕博连读；

 2004年7月-2008年8月    美国马萨诸塞州大学医学院，神经生物学，博士后；

 2008年8月-2019年6月    东南大学，生命科学研究院，教授；

 2019年6月-现在         东南大学，生命科学与技术学院，教授。

研究方向：孤独症致病机制研究

     儿童孤独症谱系障碍是一种常见的神经发育障碍性疾病，其发病率约1%。孤独症的核心临床症状包括社会交往障碍和重复呆板的动作，不同的孤独症患者还伴随如智力障碍、癫痫、睡眠障碍等临床症状。目前人们对于儿童孤独症的致病机制尚不完全清楚。本实验室以果蝇和小鼠为模式动物，运用生物化学与分子生物学、细胞生物学、遗传学、神经生物学、电生理学及行为学解析孤独症关键致病基因的分子功能及孤独症的致病机制。

近期代表性论文：（* 通讯作者; # 第一作者）

1.   Liu J, Wang Y, Liu X, Han J*, Tian Y* (2024). Spatiotemporal changes in Netrin/Dscam1 signaling dictate axonal projection direction in Drosophila small ventral lateral clock neurons. Elife. 13:RP96041. doi: 10.7554/eLife.96041.

2.     Liu X, Xie H, Liu W, Zuo J, Li S, Tian Y, Zhao J, Bai M, Li J, Bao L, Han J*, Zhang ZC* (2024). Dynamic regulation of alternative polyadenylation by PQBP1 during neurogenesis. Cell Rep. 43:114525.

3.    Huang X, Cheng S*, Han J* (2024). Polyglutamine binding protein 1 regulates neurite outgrowth through recruiting N-WASP. J Biol Chem. 300(8):107537.

4.     Wang R, Sun H, Cao Y, Zhang Z, Chen Y, Wang X, Liu L, Wu J, Xu H, Wu D, Mu C, Hao Z, Qin S, Ren H*, Han J*, Fang M*, Wang G* (2024). Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice. Sci Signal. 17:eadk8249.

5.   Liu W^#, Xie H^#, Liu X^#, Xu S, Cheng S, Wang Z, Xie T, Zhang ZC*, Han J* (2023). PQBP1 regulates striatum development through balancing striatal progenitor proliferation and differentiation. Cell Rep. 42:112277.

6.    Jin X^#, Tian Y^#, Zhang ZC, Gu P, Liu C, Han J*(2021). A subset of DN1p neurons integrates thermosensory inputs to promote wakefulness via CNMa signaling. Curr Biol. 31:2075-2087.

7.    Shen Y^#, Zhang ZC^#,*, Cheng S^#, Liu A, Zuo J, Xia S, Liu X, Liu W, Jia Z, Xie W, Han J* (2021). PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation. Mol Cell, 81:1425-1438.

8.      Wu J, Ji X, Gu Q, Liao B, Dong W*, Han J* (2021). Parallel Synaptic Acetylcholine Signals Facilitate Large Monopolar Cell Repolarization and Modulate Visual Behavior in Drosophila. J Neurosci. 41:2164-2176.

9.     Gu Q^#, Wu J^#, Tian Y, Cheng S, Zhang ZC*, Han J* (2020). Gαq splice variants mediate phototransduction, rhodopsin synthesis, and retinal integrity in Drosophila. J Biol Chem. 295:5554-5563. (Cover Story).

10.   Mu Y, Tian Y, Zhang ZC*, Han J* (2019). Metallophosphoesterase regulates light-induced rhodopsin endocytosis by promoting an association between arrestin and the adaptor protein AP2. J Biol Chem. 294:12892-12900. (Cover Story).

11.   Li Q^#, Li Y^#, Wang X^#, Qi J, Jin X, Tong H, Zhou Z, Zhang ZC, Han J* (2017). Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABAA Receptor. Curr Biol. 27:3616-3625.

12.   Liu L^#, Tian Y^#, Zhang XY, Zhang X, Li T, Xie W, Han J* (2017). Neurexin Restricts Axonal Branching in Columns by Promoting Ephrin Clustering. Dev Cell. 41:94-106. (Cover Story)

13.   Wang X, Mu Y, Sun M, Han J* (2017). Bidirectional regulation of fragile X mental retardation protein phosphorylation controls rhodopsin homoeostasis.J Mol Cell Biol. 9:104-116.

14. Wan D^#, Zhang ZC^#, Zhang X, Li Q, Han J* (2015). X chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs. Hum Mol Genet. 24:4599-614.

15.   Li T, Tan Y, Li Q, Chen H, Lv H, Xie W, Han J* (2015). The Neurexin-NSF interaction regulates short-term synaptic depression. J Biol Chem. 290:17656-67. (Cover Story).

16.   Hu W, Wang T, Wang X, and Han J* (2015). Ih Channels Control Feedback Regulation from Amacrine Cells to Photoreceptors. PLoS Biology. 13:e1002115.

17.   Li Y^#, Zhou Z^#, Zhang X, Tong H, Li P, Zhang ZC, Jia Z, Xie W*, Han J* (2013). Drosophila Neuroligin 4 Regulates Sleep through Modulating GABA Transmission.  J Neurosci. 33:15545-54.

18.  Tian Y, Li T, Sun M, Wan D, Li Q, Li P, Zhang Z, Han J*, Wei Xie* (2013). Neurexin Regulates Visual Function via Mediating Retinoid Transport to Promote Rhodopsin Maturation. Neuron 77: 311-322.

19.   Hu W, Wan D, Yu X, Cao J, Guo P, Li HS, Han J* (2012). Protein Gq modulates termination of phototransduction and prevents retinal degeneration. J Biol Chem 287:13911-8.

20.   Cao J^#, Li Y^#, Xia W, Reddig K, Hu W, Xie W, Li HS*, Han J* (2011). A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin. EMBO J 30: 3701-13.

21.   Han J^#, Reddig K and Li HS* (2007). Prolonged Gq activity triggers fly rhodopsin endocytosis and degradation and reduces photoreceptor sensitivity. EMBO J 26:4966-73.

22.   Han J^#, Gong P^#, Reddig K^#, Mitra M, Guo P and Li HS* (2006). The fly CAMTA transcription factor potentiates deactivation of the G protein-coupled light receptor rhodopsin. Cell 127: 847-858.