邢广林

发布者:吴晓纯发布时间:2022-08-12浏览次数:10762


邢广林 教授江苏特聘教授博士生导师


E-mail: guanglinxing@seu.edu.cn


办公地点:东南大学四牌楼校区五五楼342






个人简介


本科毕业于安徽师范大学,博士毕业于东南大学随后于美国奥古斯塔大学、凯斯西储大学博士后研究。20222月入职东南大学生命科学与技术学院,担任教授。获国家自然科学基金面上项目、江苏特聘教授特别支持项目、南京市留学人员科技创新项目等资助。


 

研究方向


突触是神经元与靶细胞之间形成的特殊连接,导神经信号传递,在神经环路形成、脑功能行使中扮演重要作用。突触结构或功能异常可导致精神疾病、运动障碍等问题本课题组利用小鼠等模式生物,以神经肌肉接头(运动神经元与肌肉之间形成的突触)为研究对象,综合运用细胞生物学、分子生物学、电生理等手段,揭示突触形成成熟调控机制,并探究运动神经退行性疾病——肌萎缩性侧束硬化症(也被称为渐冻症)的发病机制和治疗策略


 

代表性论文:


1)Guanglin Xing, Hongyang Jing, Zheng Yu, Peng Chen, Hongsheng Wang, Wen-Cheng Xiong*, and Lin Mei*. Membraneless condensates by rapsyn phase separation as a platform for neuromuscular junction formation. Neuron, 2021, https://doi.org/10.1016/j.neuron.2021.04.021, Cover Story, Volume 109, Issue 12.

2)Guanglin Xing, Wen-Cheng Xiong, and Lin Mei*. (2020). Rapsyn as a signaling and scaffolding molecule in NMJ formation and maintenance. Neuroscience Letters, 135013. doi.org/10.1016/j.neulet.2020.135013, Review.

3)Guanglin Xing#, Hongyang Jing#, Lei Zhang, Yu Cao, Lei Li, Kai Zhao, Zhaoqi Dong, Wenbing Chen, Hongsheng Wang, Rangjuan Cao, Wen-Cheng Xiong, and Lin Mei* (2019). A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome. eLife 2019; 8: e49180 DOI: 10.7554/eLife. 49180.

4)Guanglin Xing#, Moyi Li#, Yichen Sun, Menglong Rui, Yan Zhuang, Huihui Lv, Junhai Han, Zhengping Jia*, and Wei Xie*. (2018). Neurexin-Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction. eLife 2018; 7: e30457 DOI: 10.7554/eLife.30457.

5)Guanglin Xing#, Guangming Gan#, Dandan Chen, Mingkuan Sun, Jukang Yi, Huihui Lv, unhai Han, and Wei Xie*. (2014). Drosophila neuroligin3 regulates neuromuscular junction development and synaptic differentiation. The Journal of Biological Chemistry 289, 31867-31877; a paper of the week.

6)Zhibing Tan#, Heath L. Robinson#, Dong-Min Yin, Yu Liu, Fang Liu, Hongsheng Wang, Thiri W. Lin, Guanglin Xing, Lin Gan, Wen-Cheng Xiong, and Lin Mei* (2018). Dynamic ErbB4 Activity in Hippocampal-Prefrontal Synchrony and Top-Down Attention in Rodents. Neuron 98, 380-393 e384.

7)Lei Li#, Yu Cao#, Haitao Wu, Xinchun Ye, Zhihui Zhu, Guanglin Xing, Chenyong Shen, Arnab Barik, Bin Zhang, Xiaoling Xie, Wenbo Zhi, Lin Gan, Huabo Su, Wen-Cheng Xiong, and Lin Mei*. (2016). Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation. Neuron 92, 1007-1019.

8)Mingkuan Sun, Guanglin Xing, Liudi Yuan, Guangmin Gan, David Knight, Sheila lrene With, He Cui, Han, Junhai Han, Xiankun Zeng, Ming Fang, Gabeielle L. Boulianne, and Wei Xie*. (2011). Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction. The Journal of Neuroscience, 31, 687-699.