高山，东南大学，首席教授，博导
办公地点：东南大学科技产业园（栖霞区）高等研究院
个人简介：
英国牛津大学医学肿瘤学博士，先后在牛津和剑桥大学从事科研工作。主要研究方向聚焦在肿瘤驱动突变及其表观调控和免疫逃逸机制研究。以通讯作者在Proc Natl Acad Sci U S A（3篇）、Nature Communications、Journal Experimental Medicine、Science Advances、Cancer Research（2篇）、Cell Reports等杂志发表30多篇论文。公开专利19项（包括三个国际PCT），获得授权9个（包括国际PCT专利一项）。
研究方向：
肿瘤驱动突变、表观调控和分子机理；
药物机理和生物标志物
肿瘤免疫治疗技术和分子机理
代表文章（均为最后/唯一通讯作者）
1. Pan, Y., Gu, Y., Liu, T., Zhang, Q., Yang, F., Duan, L., Cheng, S., Zhu, X., Xi, Y., Chang, X., Ye, Q. & Gao, S. Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression. Proceedings of the National Academy of Sciences of the United States of America 120, e2302291120, doi:10.1073/pnas.2302291120 (2023).
2. Yang, X., Wen, Y., Liu, S., Duan, L., Liu, T., Tong, Z., Wang, Z., Gu, Y., Xi, Y., Wang, X., Luo, D., Zhang, R., Liu, Y., Wang, Y., Cheng, T., Jiang, S., Zhu, X., Yang, X., Pan, Y., Cheng, S., Ye, Q., Chen, J*., Xu, X*. & Gao, S*. LCDR regulates the integrity of lysosomal membrane by hnRNP K-stabilized LAPTM5 transcript and promotes cell survival. Proceedings of the National Academy of Sciences of the United States of America 119, doi:10.1073/pnas.2110428119 (2022).
3. Wang, X., Yang, X., Zhang, C., Wang, Y., Cheng, T., Duan, L., Tong, Z., Tan, S., Zhang, H., Saw, P. E., Gu, Y., Wang, J., Zhang, Y., Shang, L., Liu, Y., Jiang, S., Yan, B., Li, R., Yang, Y., Yu, J., Chen, Y., Gao, G. F*., Ye, Q. & Gao, S. Tumor cell-intrinsic PD-1 receptor is a tumor suppressor and mediates resistance to PD-1 blockade therapy. Proceedings of the National Academy of Sciences of the United States of America 117, 6640-6650, doi:10.1073/pnas.1921445117 (2020).
4. Wang XT., Liu TF., Zhang C., Gu YM., Cheng SW., Duan LQ., Zhang JH., Yin R., Zhao XJ., Shang M., Li YF., Ding A., Cheng TY., Wu SZ. & Gao, S. A splicing isoform of PD-1 promotes tumor progression as a potential immune checkpoint. Nature Communications. 15(1):9114. doi: 10.1038/s41467-024-53561-2 (2024).
5. Wen Y., Yang X., Li Y., Zhao X., Ding A., Song D., Duan L., Cheng S., Zhu X., Peng B., Chang X., Zhang C., Yang F., Cheng T., Wang H., Zhang Y., Zhang T., Zheng S., Ren L*. & Gao S*. DRAIC mediates hnRNPA2B1 stability and m6A-modified IGF1R instability to inhibit tumor progression. Oncogene. 43 :2266-2278. doi: 10.1038/s41388-024-03071-8 (2024).
6. Peng B., Cheng S., Wang H., Liu T., Gu Y., Duan L., Cheng T., Wang X., Wang X., Zhang Q., Zhang Y., Zhao X., Yao X., Zhao X., Song D*., Zeng J*., Gao S*. N6-methyladenosine enhances the expression of TGF-β-SMAD signaling family to inhibit cell growth and promote cell metastasis. Cancer Letters 28, 217195, doi: 10.1016/j.canlet.2024.217195 (2024).
7. Jiang S., Han X., Liu T., He Y., Zhao Z., Liu T., Cheng S., Zhang J., Duan L., Liu Y., Cheng T., Liu Y., Ye Q., Gao S. HUNK inhibits cargo uptake and lysosomal traffic in the caveolar pathway via the AGAP3/ARF6. Science Bulletin (Beijing) 69, 173-178, doi: 10.1016/j.scib.2023.11.053 (2024).
8. Han, X., Jiang, S., Gu, Y., Ding, L., Zhao, E., Cao, D., Wang, X., Wen, Y., Pan, Y., Yan, X., Duan, L., Sun, M., Zhou, T., Liu, Y., Hu, H*., Ye, Q*. & Gao, S*. HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1. Cell Death & Disease 14, 327, doi:10.1038/s41419-023-05849-2 (2023).
9. Zhu, Y., Liu, X., Wang, Y., Pan, Y., Han, X., Peng, B., Zhang, X., Niu, S., Wang, H., Ye, Q., Gu, Y*. & Gao, S*. DMDRMR promotes angiogenesis via antagonizing DAB2IP in clear cell renal cell carcinoma. Cell Death & Disease 13, 456, doi:10.1038/s41419-022-04898-3 (2022).
10. Gu, Y., Niu, S., Wang, Y., Duan, L., Pan, Y., Tong, Z., Zhang, X., Yang, Z., Peng, B., Wang, X., Han, X., Li, Y., Cheng, T., Liu, Y., Shang, L., Liu, T., Yang, X., Sun, M., Jiang, S., Zhang, C., Zhang, N., Ye, Q. & Gao, S. DMDRMR-Mediated Regulation of m(6)A-Modified CDK4 by m(6)A Reader IGF2BP3 Drives ccRCC Progression. Cancer Research 81, 923-934, doi:10.1158/0008-5472.Can-20-1619 (2021).
11. Jiang, S., Wang, X., Song, D., Liu, X., Gu, Y., Xu, Z., Wang, X., Zhang, X., Ye, Q., Tong, Z., Yan, B., Yu, J., Chen, Y., Sun, M., Wang, Y. & Gao, S. Cholesterol Induces Epithelial-to-Mesenchymal Transition of Prostate Cancer Cells by Suppressing Degradation of EGFR through APMAP. Cancer Research 79, 3063-3075, doi:10.1158/0008-5472.Can-18-3295 (2019).
