Nannan Chen Professor
Email: nannanchen27@seu.edu.cn
Address：Huichuan B401
Biography:
Nannan Chen received her bachelor's degree from Zhejiang University, and her doctoral degree from Institute of Biophysics, Chinese Academy of Sciences. She then pursued postdoctoral research at Brandeis University. In October 2023, she was appointed as a professor in the School of Life Sciences and Technology at Southeast University.
Research:
Neurons communicate by releasing neurotransmitters. Traditional views consider neurotransmission to be singular and stable; however, the discovery of co-transmission and neurotransmitter switching challenges this perspective. Furthermore, abnormalities in neurotransmission have been observed in various neurological disorders. Using Drosophila melanogaster as a model organism, we investigate the fundamental principle of co-transmisson and neurotransmitter switching, as well as the pathogenic mechanisms underlying neurotransmission abnormalities in neurological diseases.
Publications：
1. Ivy Chi Wai Chan*, Nannan Chen*, John Hernandez*, Hagar Meltzer*, Annie Park*, Aaron Stahl*. “Future avenues in Drosophila mushroom body research.” Learning & Memory 2024 (Co-first author, review).
2. Nannan Chen*, Yunpeng Zhang*, Emmanuel J. Rivera-Rodriguez*, Albert D. Yu, Michael Hobin, Michael Rosbash and Leslie C. Griffith. “Widespread posttranscriptional regulation of cotransmission”. Science Advances 2023 (Co-first author)
3. Nannan Chen, Yunpeng Zhang, Mohamed Adel, Elena A. Kuklin, Martha L. Reed, Jacob D. Mardovin, Baskar Bakthavachalu, K. VijayRaghavan, Mani Ramaswami and Leslie C. Griffith. “Local translation provides the asymmetric distribution of CaMKII required for associative memory formation”, Current Biology 2022
4. Mohamed Adel, Nannan Chen, Yunpeng Zhang, Martha L. Reed, Christina Quasney and Leslie C. Griffith. “Pairing-dependent plasticity in a dissected fly brain is input-specific and requires synaptic CaMKII enrichment and nighttime sleep”, Journal of Neuroscience 2022
5. Mingmin Zhou*, Nannan Chen*, Jingsong Tian, Jianzhi Zeng, Yunpeng Zhang, Xiaofan Zhang, Jing Guo, Jinghan Sun, Yulong Li, Aike Guo, Yan Li. “Suppression of GABAergic neurons through D2-like receptor secures efficient conditioning in Drosophila aversive olfactory learning”, PNAS 2019. (Co-first author)
6. Nannan Chen, Aike Guo and Yan Li. “Aging accelerates memory extinction and impairs memory restoration in Drosophila”, Biochemical and Biophysical Research Communications 2015.
7. Yan Yin, Nannan Chen., Shixing Zhang and Aike Guo. “Choice strategies in Drosophila are based on competition between olfactory memories”, European Journal of Neuroscience 2009.
