Guanglin Xing, PhD
Professor, Jiangsu Distinguished Professor
Huichuan Building A407/409
Education and training
Anhui Normal University, Bachelor, 2006
Southeast University, PhD, 2013
Case Western Reserve University, Postdoc, 2022
Research Interests
The nervous system is one of the most critical systems in animals, responsible for regulating various high-level functions such as learning, memory, movement, emotion, and thought. Its operation principle involves the synaptic connections between neurons, forming a complete network to achieve the reception, processing, and transmission of information. The human brain contains approximately 100 billion neurons, with each neuron distributed with thousands to tens of thousands of synapses, resulting in a total of trillions of synapses in the entire brain. These synapses play a central role in the information processing of the nervous system, and almost all brain function abnormalities are closely related to changes in synaptic function.
Our research group mainly focuses on the study of synaptic formation and the pathogenesis of neurodegenerative diseases. We utilize model organisms such as mice in combination with cell biology, molecular biology, and electrophysiology techniques to systematically reveal the regulatory mechanisms of synaptic formation and maturation, as well as the pathogenesis of motor neuron degenerative diseases and their potential therapeutic strategies.
Publications
1. Guanglin Xing, Hongyang Jing, Zheng Yu, Peng Chen, Hongsheng Wang, Wen-Cheng Xiong*, and Lin Mei*. Membraneless condensates by rapsyn phase separation as a platform for neuromuscular junction formation. Neuron, 2021, https://doi.org/10.1016/j.neuron.2021.04.021, Cover Story, Volume 109, Issue 12.
2. Guanglin Xing, Wen-Cheng Xiong, and Lin Mei*. (2020). Rapsyn as a signaling and scaffolding molecule in NMJ formation and maintenance. Neuroscience Letters, 135013. doi.org/10.1016/j.neulet.2020.135013, Review.
3. Guanglin Xing#, Hongyang Jing#, Lei Zhang, Yu Cao, Lei Li, Kai Zhao, Zhaoqi Dong, Wenbing Chen, Hongsheng Wang, Rangjuan Cao, Wen-Cheng Xiong, and Lin Mei* (2019). A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome. eLife 2019; 8: e49180 DOI: 10.7554/eLife. 49180.
4. Guanglin Xing#, Moyi Li#, Yichen Sun, Menglong Rui, Yan Zhuang, Huihui Lv, Junhai Han, Zhengping Jia*, and Wei Xie*. (2018). Neurexin-Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction. eLife 2018; 7: e30457 DOI: 10.7554/eLife.30457.
5. Guanglin Xing#, Guangming Gan#, Dandan Chen, Mingkuan Sun, Jukang Yi, Huihui Lv, unhai Han, and Wei Xie*. (2014). Drosophila neuroligin3 regulates neuromuscular junction development and synaptic differentiation. The Journal of Biological Chemistry 289, 31867-31877; a paper of the week.
6. Zhibing Tan#, Heath L. Robinson#, Dong-Min Yin, Yu Liu, Fang Liu, Hongsheng Wang, Thiri W. Lin, Guanglin Xing, Lin Gan, Wen-Cheng Xiong, and Lin Mei* (2018). Dynamic ErbB4 Activity in Hippocampal-Prefrontal Synchrony and Top-Down Attention in Rodents. Neuron 98, 380-393 e384.
7. Lei Li#, Yu Cao#, Haitao Wu, Xinchun Ye, Zhihui Zhu, Guanglin Xing, Chenyong Shen, Arnab Barik, Bin Zhang, Xiaoling Xie, Wenbo Zhi, Lin Gan, Huabo Su, Wen-Cheng Xiong, and Lin Mei*. (2016). Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation. Neuron 92, 1007-1019.
8. Mingkuan Sun, Guanglin Xing, Liudi Yuan, Guangmin Gan, David Knight, Sheila lrene With, He Cui, Han, Junhai Han, Xiankun Zeng, Ming Fang, Gabeielle L. Boulianne, and Wei Xie*. (2011). Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction. The Journal of Neuroscience, 31, 687-699.
