Yuxuan Luo
Education & Experience
Graduated from Sichuan University with a bachelor's degree in biology in 2009; received Ph.D. degree from Peking Union Medical College (Tsinghua University Health Science Center) in 2014; engaged in research work in the Second Affiliated Hospital of Chongqing Medical University from 2014 to 2017; conducted postdoctoral research at the University of Texas Southwestern Medical Center in the United States from 2017 to 2021; joined Southeast University in 2022 as a young chief professor, and was selected for the Excellent Young Scientists Fund Program.
Research interests: pathogenesis of cardiovascular diseases
Cardiovascular disease is the number one killer of human health, seriously affecting people's life quality and threatening human life and health, and the morbidity is increasing year by year. Until now, the pathogenesis of cardiovascular diseases is not fully understood. The Yuxuan Luo lab focuses on the pathogenesis of cardiovascular diseases. We use approaches that span biomedical disciplines, integrating genetics in lab models, tissue culture and multi-omics. Our work has yielded exciting insights about the roles of signaling pathways, transcriptional regulation, protein post-translational modifications and mitochondrial metabolism in cardiac hypertrophy and myocardial injury.
Publications
1. Xiaoxuan Zhong, Xiang Wei, Yan Xu, Xuehai Zhu, Bo Huo, Xian Guo, Gaoke Feng, Zihao Zhang, Xin Feng, Zemin Fang, Yuxuan Luo*, Xin Yi*, Ding-Sheng Jiang*. The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis. Acta Pharmaceutica Sinica B, 2024;14(2):712-728.
2. Dan Tong, Gabriele G. Schiattarella, Nan Jiang, Daniel Daou, Yuxuan Luo, Mark S. Link, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill. Impaired AMP-Activated Protein Kinase Signaling in Heart Failure With Preserved Ejection Fraction–Associated Atrial Fibrillation. Circulation. 2022;146:73–76.
3. Yuxuan Luo, Nan Jiang, Herman I. May, Xiang Luo, Anwarul Ferdous, Gabriele G. Schiattarella, Guihao Chen, Qinfeng Li, Chao Li, Beverly A. Rothermel, Dingsheng Jiang, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill. Cooperative binding of ETS2 and NFAT link Erk1/2 and calcineurin signaling in the pathogenesis of cardiac hypertrophy. Circulation. 2021;144:34-51.
4. Anwarul Ferdous, Sarvjeet Singh, Yuxuan Luo, Md. J. Abedin, Nan Jiang, Cameron E. Perry, Bret M. Evers, Thomas G. Gillette, Michael Kyba, Maria Trojanowska, Joseph A. Hill. Fli1 Promotes Vascular Morphogenesis by Regulating Endothelial Potential of Multipotent Myogenic Progenitors. Circulation Research. 2021;129:949–964.
5. Gabriele G. Schiattarella, Francisco Altamirano, Soo Young Kim, Dan Tong, Anwarul Ferdous, Hande Piristine , Subhajit Dasgupta, Xuliang Wang, Kristin M. French, Elisa Villalobos, Stephen B. Spurgin, Maayan Waldman, Nan Jiang, Herman I. May, Theodore M. Hill, Yuxuan Luo, Heesoo Yoo, Vlad G. Zaha, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill. Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction. Nature Communications, 2021; 12:1684.
6. Anwarul Ferdous, Zhao V. Wang, Yuxuan Luo, Dan L. Li, Xiang Luo, Gabriele G. Schiattarella, Francisco Altamirano, Herman I. May, Pavan K. Battiprolu, Annie Nguyen, Beverly A. Rothermel,Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill. FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth. Nature Communications, 2020;11:2551.
7. Yu-Xuan Luo#, Xiaoqiang Tang#, Xi-Zhou An, Xue-Min Xie, Xiao-Feng Chen, Xiang Zhao, De-Long Hao, Hou-Zao Chen, De-Pei Liu. Sirt4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. European Heart Journal, 2017. 38(18): p. 1389-1398.
8. Xi Jiang#, Ke-Qiong Deng#, Yu-Xuan Luo#, Ding-Sheng Jiang, Lu Gao, Xiao-Fei Zhang, Peng Zhang, Guang-Nian Zhao, Xueyong Zhu, Hongliang Li. Tumor Necrosis Factor Receptor–Associated Factor 3 Is a Positive Regulator of Pathological Cardiac Hypertrophy. Hypertension, 2015. 66(2): p. 356-67.
9. Yuan Zhang, Jing Xu, Yu-Xuan Luo, Xi-Zhou An, Ran Zhang, Guang Liu, Hongliang Li, Hou-Zao Chen, De-Pei Liu. Overexpression of Mitofilin in the Mouse Heart Promotes Cardiac Hypertrophy in Response to Hypertrophic Stimuli. Antioxid Redox Signal, 2014. 21(12): p. 1693-707.
10. Ding-Sheng Jiang#, Yu-Xuan Luo#, Ran Zhang#, Xiao-Dong Zhang, Hou-Zao Chen, Yan Zhang, Ke Chen, Shu-Min Zhang, Guo-Chang Fan, Peter P. Liu, De-Pei Liu, Hongliang Li. Interferon Regulatory Factor 9 Protects Against Cardiac Hypertrophy by Targeting Myocardin. Hypertension, 2014. 63(1): p. 119-27.
