Yanan Wang, Ph.D.
Associate Researcher
Email: wangyananemail@seu.edu.cn
Personal Profile:
l Graduated with a Bachelor's degree from the University of Electronic Science and Technology of China (UESTC) in 2008.
l Graduated with a Master's degree from the University of Electronic Science and Technology of China (UESTC) in 2011.
l Graduated with a PhD from Zhejiang University in 2015.
l Postdoctoral researcher at Augusta University, USA (October 2015 - September 2017).
l Postdoctoral researcher and Senior Research Associate at the University of Texas Southwestern Medical Center (UTSW), USA (October 2017 - June 2023).
l Since September 2023, Associate Researcher at the School of Life Science and Technology, Southeast University.
Research Focus:
The regulatory role of epigenetic modifications in neural development.
Epigenetic modifications, including DNA methylation and histone demethylation, are critical for proper nervous system development. Dysregulation of epigenetic processes has been implicated in a range of neurological disorders, such as autism spectrum disorders and schizophrenia. Utilizing mouse models, we integrate advanced approaches in cell biology, molecular biology, electrophysiology, and behavioral science to investigate the mechanisms by which epigenetic modifications govern neural development. Additionally, we aim to uncover the pathophysiological underpinnings of autism and explore potential therapeutic strategies.
Publications:
1. Wang Y, Khandelwal N, Liu S, Zhou M, Bao L, Wang JE, Kumar A, Xing C, Gibson J, Wang Y*. KDM6B cooperates with Tau and regulates synaptic plasticity and cognition via inducing VGLUT1/2. Molecular Psychiatry 2022: 1-14.
2. Wang YN#, Figueiredo D#, Sun XD#, Dong ZQ, Chen WB, Cui WP, Liu F, Wang HS, Li HW, Robinson H, Fei EK, Pan BX, Li BM, Xiong WC, Mei L*. Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. Proc Natl Acad Sci U S A 2018; 115(10): 2508-2513.
3. Wang YN, Zhou L, Li YH, Wang Z, Li YC, Zhang YW, Wang Y, Liu G, Shen Y*. Protein Interacting with C-Kinase 1 Deficiency Impairs Glutathione Synthesis and Increases Oxidative Stress via Reduction of Surface Excitatory Amino Acid Carrier 1. J Neurosci 2015; 35(16): 6429-6443.
4. Yang M, Wang C, Zhou M, Bao L, Wang Y, Kumar A, Xing C, Luo W, Wang Y*. KDM6B promotes PARthanatos via suppression of O6-methylguanine DNA methyltransferase repair and sustained checkpoint response. Nucleic Acids Res 2022; 50(11): 6313-6331.
5. Wang Y, Chen Y, Wang C, Yang M, Wang Y, Bao L, Wang JE, Kim B, Chan KY, Xu W, Capota E, Ortega J, Nijhawan D, Li GM, Luo W, Wang Y*. MIF is a 3' flap nuclease that facilitates DNA replication and promotes tumor growth. Nat Commun 2021; 12(1): 2954.
