GUAN Wenyue
Ph.D.
Associated Investigator
e-mail:wenyue.guan@seu.edu.cn
office: Liwenzheng Building, Sipailou Campus
Academic Background
2006-2010: B.S. Bioscience
Henan Normal University, Henan, China
2010-2012: Master Epigenetic
East China Normal University, Shanghai, China
2012-2017: Ph.D. Biochemistry and Molecular Biology
ENS de Lyon , Lyon, France
2017-2022: Postdoctoral Fellow
Institute of Functional Genomics of Lyon & National Center of Scientific Research in France
2022-2024: Associated Investigator
Changping Laboratory
2024-now: Associated Investigator
School of Life Science and Technology, Southeast University
Research Interest
1. The developmental origins and regulatory mechanisms of neuronal sexual dimorphism;
2. Exploring the link between the developmental origins of neurons and their functional specialization.
Representative Publications:
1. Wenyue Guan; Ziyan Nie; Anne Laurençon; Mathilde Bouchet; Christophe Godin; Chérif Kabir; Aurelien Darnas; Jonathan Enriquez; The role of Imp and Syp RBPs in precise neuronal elimination by apoptosis through the regulation of TFs, Elife. 2024 Oct 4;12:RP91634.
2. Mathilde Bouchet; Séverine Urdy; Wenyue Guan; Chérif Kabir; Steve Garvis; Jonathan Enriquez ; A simple smiFISH pipeline to quantify mRNAat the single-cell level in 3D, STAR protocols, 2023, 4(2).
3. Wenyue Guan; Stéphanie Bellemin; Mathilde Bouchet; Lalanti Venkatasubramanian; Camille Guillermin; Anne Laurençon; Kabir Chérif; Aurélien Darnas; Christophe Godin; Séverine Urdy; Richard Mann; Jonathan Enriquez; Post-Transcriptional Regulation of Transcription Factor Codes in Immature Neurons Drives Neuronal Diversity, Cell Reports, 2022, 39(13).
4. Wenyue Guan; Romain Guyot; Frédéric Flamant; Two protocols to study the interactions of thyroid hormone receptors with other proteins and chromatin, Methods in Molecular Biology, 2018.6, 1801: 9-16.
5. Wenyue Guan; Lalanti Venkatasubramanian; Myungin Baek; Richard S Mann; Jonathan Enriquez; Visualize Drosophila Leg Motor Neuron Axons Through the Adult Cuticle, Journal of Visualized Experiments, 2018, (140).
6. Suzy Markossian; Romain Guyot; Sabine Richard; Marie Teixeira; Nadine Aguilera; Mathilde Bouchet; Michelina Plateroti; Wenyue Guan; Karine Gauthier; Denise Aubert; Frédéric Flamant; CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone, Thyroid, 2018.11, 28(1): 139-150.
7. Wenyue Guan; Romain Guyot; Jacques Samarut; Frédéric Flamant; Jiemin Wong; Karine Gauthier; Methylcytosine dioxygenase TET3 interacts with thyroid hormone nuclear receptors and stabilizes their association to chromatin, PNAS, 2017, 114(31): 8229-8234.
