Prof. Lin Ling
Telephone: 13851960322
E-mail: linglin1000@163.com
Address: No.2 Dongda Road, Pukou, Nanjing, Huichuan Building D104
Education:
Bachelor of Biological Sciences, 2004-2008
The Anhui Agricultural University, China
Master of Special Economic Animals, 2009-2012
The Anhui Agricultural University, China
Ph.D. of Aeronautical and Astronautical Science and Biotechnology, 2012-2015
The Northwestern Polytechnical University & CAS of Chinese Academy of Sciences, China
Postdoctoral Fellow, 2015-2018
The University of California, Riverside, USA
Position:
Project Scientist, 2018-2022
The University of California, Riverside, USA
Professor, 2022-now
The Southeast University, China
Research Interests: Molecular regulation of pest development, reproduction, and behavior
Mosquitoes are vectors of numerous dangerous diseases, posing a significant threat to human health. These insects undergo morphological reorganization and behavioral adaptations throughout their life cycle to accommodate developmental, functional, and environmental changes specific to each stage. The blood-feeding reproductive strategy adopted by adult female mosquitoes not only enhances the population's dispersal capacity, making them a globally invasive species, but also serves as the primary mechanism for biting humans and facilitating pathogen acquisition and transmission. Utilizing genome editing technology, our laboratory integrates interdisciplinary approaches, including microRNA regulation, signaling pathway cross-linking, hormone interactions, tissue communication, in vivo protein localization, and biomics big data analysis, to identify molecular targets and regulatory networks for pest control.
Publications:
1. Lin Ling, Alexander S Raikhel*. Amino acid-dependent regulation of insulin-like peptide signaling is mediated by TOR and GATA factors in the disease vector mosquito Aedes aegypti. Proceedings of the National Academy of Sciences of the United States of America. 2023, 120(34): e2315166120.
2. Lin Ling, Alexander S Raikhel*. Cross-talk of insulin-like peptides, juvenile hormone, and 20-hydroxyecdysone in regulation of metabolism in the mosquito Aedes aegypti. Proceedings of the National Academy of Sciences of the United States of America. 2021, 118(6): e2023470118.
3. Lin Ling, Alexander S Raikhel*. Serotonin signaling regulates insulin-like peptides for growth, reproduction, and metabolism in the disease vector Aedes aegypti. Proceedings of the National Academy of Sciences of the United States of America. 2018, 115(42): E9822-E9831.
4. Lin Ling, Vladimir A Kokoza, Changyu Zhang, Emre Aksoy, Alexander S Raikhel*. MicroRNA-277 targets insulin-like peptides 7 and 8 to control lipid metabolism and reproduction in Aedes aegypti mosquitoes. Proceedings of the National Academy of Sciences of the United States of America. 2017, 114(38): E8017-E8024.
5. Lin Ling, Xie Ge, Zhiqian Li, Baosheng Zeng, Jun Xu, Xu Chen, Peng Shang, Anthony A James, Yongping Huang*, Anjiang Tan*. MiR-2 family targets awd and fng to regulate wing morphogenesis in Bombyx mori. RNA Biology. 2015, 12(7): 742-748.
6. Lin Ling, Xie Ge, Zhiqian Li, Baosheng Zeng, Jun Xu, Abu Faiz Md Aslam, Qisheng Song, Peng Shang, Yongping Huang*, Anjiang Tan*. MicroRNA Let-7 regulates molting and metamorphosis in the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology. 2014, 53:13-21.
7. Lin Ling, Xuelan Liu, Jiaping Xu*, Zhengying You, Jingbo Zhou. Silkworm eggs: An ideal model for studying the biological effects of low energy Ar+ ion interaction in animals. Nuclear Instruments and Methods in Physics Research B. 2011, 269(18): 1997-2000.
8. Zulian Liu, Jun Xu, Lin Ling, Xingyu Luo, Dehong Yang, Xu Yang, Xiaoqian Zhang, Yongping Huang*. miR-34 regulates larval growth and wing morphogenesis by directly modulating ecdysone signaling and cuticle protein in Bombyx mori. RNA Biology. 2020, 17(9): 1342-1351.
9. Dujuan Dong, Yang Zhang, Vlastimil Smykal, Lin Ling, Alexander S Raikhel*. HR38, an ortholog of NR4A family nuclear receptors, mediates 20-hydroxyecdysone regulation of carbohydrate metabolism during mosquito reproduction. Insect Biochemistry and Molecular Biology. 2018, 96: 19-26.
10. Zulian Liu, Lin Ling, Jun Xu, Baosheng Zeng, Yongping Huang, Peng Shang, Anjiang Tan*. MicroRNA-14 regulates larval development time in Bombyx mori. Insect Biochemistry and Molecular Biology. 2018, 93: 57-65.
11. Bo Zhao, Keira J Lucas, Tusar T Saha, Jisu Ha, Lin Ling, Vladimir A Kokoza, Sourav Roy, Alexander S Raikhel*. MicroRNA-275 targets sarco/endoplasmic reticulum Ca2+ adenosine triphosphatase (SERCA) to control key functions in the mosquito gut. PLoS Genetics. 2017, 13(8): e1006943.
