Prof. Yufeng Pan, Ph.D.
Tel：025-83790776
E-mail: pany@seu.edu.cn
Labweb: panylab.org
Office location: Room 215, Li Wenzheng North Building, No. 2 Sipailou Road, Nanjing.
Brief CV：
Dr. Pan earned his bachelor's degree in biophysics from Nankai University in July 2004 and his Ph.D. in neurobiology from the Institute of Biophysics, Chinese Academy of Sciences in July 2009. In September 2009, he began working as a postdoctoral researcher at the Janelia Research Campus of the Howard Hughes Medical Institute in the United States. In 2014, he was appointed a professor at the School of Life Science and Technology, Southeast University. In 2016, he was awarded the National Excellent Young Scientists Fund and the Jiangsu Outstanding Youth Fund. Dr. Pan currently serves as a chief professor at Southeast University.
Research interest：molecular and neuronal basis of innate and learned behaviors
How are animal behaviors generated and regulated? Are they innate or acquired through learning? What are the neural mechanisms underlying innate and learned behaviors? How do natural differences in behavior between sexes arise? What are the molecular and neuronal mechanisms that determine the transition and choice between different behaviors (such as sleep, foraging, and courtship)? Our laboratory uses the classic model organism, the fruit fly, to investigate the genetic and neurobiological mechanisms of animal behavior through techniques such as genetics, optogenetics, behavioral analysis, molecular biology, electrophysiology, and functional imaging. For more information, please visit our lab's homepage at: panylab.org.
Representative publications：
1.Zhao, H., Jiang, X., Ma, M., Xing, L., Ji, X., and Pan, Y. (2024). A neural pathway for social modulation of spontaneous locomotor activity (SoMo-SLA) in Drosophila. PNAS, 121, e2314393121.
2.Jiang, X., Sun, M., Chen, J., and Pan, Y. (2024). Sex-Specific and State-Dependent Neuromodulation Regulates Male and Female Locomotion and Sexual Behaviors. Research, 7, 0321.
3.Sun, M., Ma, M., Deng, B., Li, N., Peng, Q., and Pan, Y. (2023). A neural pathway underlying hunger modulation of sexual receptivity in Drosophila females. Cell Reports, 42. 113243.
4.Ji, X., Li, X., Wang, L., Liu, S., Jiang, X., and Pan, Y. (2023). Asexuality in Drosophila juvenile males is organizational and independent of juvenile hormone. Embo Reports, e56898.
5.Jiang, X., and Pan, Y. (2022). Neural Control of Action Selection Among Innate Behaviors. Neuroscience Bulletin, 38, 1541-1558.
6.Han, C., Peng, Q., Sun, M., Jiang, X., Su, X., Chen, J., Ma, M., Zhu, H., Ji, X., and Pan, Y. (2022). The doublesex gene regulates dimorphic sexual and aggressive behaviors in Drosophila. PNAS, 119, e2201513119.
7.Han, C., Peng, Q., Su, X., Xing, L., Ji, X., and Pan, Y. (2022). A male-specific doublesex isoform reveals an evolutionary pathway of sexual development via distinct alternative splicing mechanisms. Communications Biology, 5, 728.
8.Peng, Q., Chen, J., and Pan, Y. (2021). From fruitless to sex: On the generation and diversification of an innate behavior. Genes Brain and Behavior, 20, e12772.
9.Jia, Y., Jin, S., Hu, K., Geng, L., Han, C., Kang, R., Pang, Y., Ling, E., Tan, E.K., Pan, Y.*, Liu, W.* (2021). Gut microbiome modulates Drosophila aggression through octopamine signaling. Nature Communications, 12, 2698.
10.Chen, J., Jin, S., Chen, D., Cao, J., Ji, X., Peng, Q., and Pan, Y. (2021). fruitless tunes functional flexibility of courtship circuitry during development. Elife, 10, e59224
11.Gao, C., Guo, C., Peng, Q., Cao, J., Shohat-Ophir, G., Liu, D., and Pan, Y. (2020). Sex and Death: Identification of Feedback Neuromodulation Balancing Reproduction and Survival. Neuroscience Bulletin, 36, 1429-1440.
12.Wu, S., Guo, C., Zhao, H., Sun, M., Chen, J., Han, C., Peng, Q., Qiao, H., Peng, P., Liu, Y., et al. (2019). Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila. Nature Communications, 10, 4770.
13.Zhang, W., Guo, C., Chen, D., Peng, Q., and Pan, Y. (2018). Hierarchical Control of Drosophila Sleep, Courtship, and Feeding Behaviors by Male-Specific P1 Neurons. Neuroscience Bulletin, 34, 1105-1110.
14.Chen, D., Sitaraman, D., Chen, N., Jin, X., Han, C., Chen, J., Sun, M., Baker, B.S., Nitabach, M.N., and Pan, Y. (2017). Genetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila. Nature Communications, 8, 154.
15.Pan, Y., and Baker, B.S. (2014). Genetic identification and separation of innate and experience-dependent courtship behaviors in Drosophila. Cell, 156, 236-248.
16.Pan, Y., Meissner, G.W., and Baker, B.S. (2012). Joint control of Drosophila male courtship behavior by motion cues and activation of male-specific P1 neurons. PNAS, 109, 10065-10070.
