Xu Hua
Distinguished Professor of Jiangsu Province，the doctoral supervisor
E-mail:xhua@seu.edu.cn
Office location：Huichuan Building B-406, in Jiangbei Campus of Southeast University
Overview：
Doctor Hua earned his Bachelor’s degree in Applied Physics from Nanjing University of Science and Technology. Then he earned his MD-PhD’s degree in succession from Nanjing University and studied for two years in Goettingen University in Germany during the PhD period. In the postdoctoral period, he worked as the postdoctoral scholar and associate research scientist in the two world-class cancer institutions in the U.S., MD Anderson Cancer Center and Columbia University. In 2024, he joined School of Life Science and Technology in Southeast University and appointed as the principal investigator and doctoral supervisor, with awarded as the Distinguished Professor of Jiangsu Province.
Research：
Our lab has focused on the intersection of genetics and bioinformatics for a long time. We’re interested in the development of new technology by combination of both dry- and wet- experiments and answering key science questions in genetics by interdisciplinary methods. The main interests include: 1) The mechanism of epigenetic inheritance between parental and daughter cells, and its role in cell functions. 2) The mechanism of genetic mutations in oncogenesis. We used methods of system biology and multi-omics analysis to study the role of cancer related mutations on gene regulatory network, revealing the key role of mutations in non-coding sequence. 3) Development of new technology based on epigenetics and genetics for non-invasive diagnosis. We have published more than 20 articles in the world famous journals such as Nature, Molecular Cell, Science Advances、Nature communications、Cancer Discovery and so on. The research findings have been cited by members of the Danish Academy and the European Academy in journals of Nature, Cell and so on.
Selected Publications：
1. Xu Hua*, Hui Zhou*, Hui-ChenWu, Julia Furnari, Corina P. Kotidis, Raul Rabadan, Jeanine M. Genkinger, Jeffrey N. Bruce, Peter Canoll, Regina M. Santella, Zhiguo Zhang+. Tumor detection by analysis of both symmetric- and hemi-methylation of plasma cell-free DNA. Nature Communications, 2024, 15(6113)
2. Albert Serra-Cardona*, Xu Hua*, Seth W. McNutt, Hui Zhou, Takenori Toda, Songtao Jia, Feixia Chu, and Zhiguo Zhang. The PCNA-Pol delta complex couples lagging strand DNA synthesis to parental histone transfer for epigenetic inheritance. Science Advances,2024
3. Yimeng Fang*, Xu Hua*, Chun-Min Shan, Takenori Toda, Feng Qiao, Zhiguo Zhang, and Songtao Jia. Coordination of histone chaperones for parental histone segregation and epigenetic inheritance. Genes Development, 2024, doi:10.1101/gad.351278.123 （封面文章）
4. Xu Hua*, Yongsheng Li*, Sairahul R. Pentaparthi*, Daniel J. McGrail*, Raymond Zou*, Li Guo*, Aditya Shrawat, Kara M. Cirillo, Qing Li, Akshay Bhat, Min Xu, Dan Qi, Ashok Singh, Francis McGrath, Steven Andrews, Kyaw Lwin Aung, Jishnu Das, Yunyun Zhou, Alessia Lodi, Gordon B. Mills, S. Gail Eckhardt, Marc L. Mendillo, Stefano Tiziani, Erxi Wu+, Jason H. Huang+, Nidhi Sahni+, and S. Stephen Yi+. Landscape of microRNA regulatory network architecture and functional rerouting in cancer. Cancer Research, 2023, 83, 59-73
5. Zhiming Li*, Shoufu Duan*, Xu Hua, Xiaowei Xu, Yinglu Li, Demis Menolfi, Hui Zhou, Chao Lu, Shan Zha, Stephen P. Goff, Zhiguo Zhang+. Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements. Nature, 2023, vol623, 643-651
6. Xiaowei Xu*, Xu Hua*, Kyle Brown, Xiaojun Ren and Zhiguo Zhang+. Mcm2 promotes stem cell differentiation via its ability to bind H3-H4. eLife, 2022, 11, e80917
7. Zhiming Li*, Xu Hua*, Albert Serra-Cardona, Xiaowei Xu, Zhiguo Zhang+. Efficient and strand-specific profiling of replicating chromatin with eSPAN in mammalian cells. Nature Protocols, 2021, 16, 2698–2721
8. Zhiming Li*, Xu Hua*, Albert Serra-Cardona*, Xiaowei Xu*, Songlin Gan, Hui Zhou, Wen-Si Yang, Chun-long Chen, Rui-Ming Xu, and Zhiguo Zhang+. DNA polymerase α interacts with H3-H4 and facilitates the transfer of parental histones to lagging strands. Science Advances, 2020, Vol. 6, no. 35, eabb5820
9. Xu Hua*, Tang Rongjun*, Xu Xiuxiu, Wang Zhi, Xu Qi, Chen Luxiao, Wingender Edgar, Li Jie+, Chenyu Zhang+ and Wang Jin+. mirTrans: a resource of transcriptional regulation on microRNAs for human cell lines. Nucleic Acids Research, 2018, Volume 46, Issue D1, 4
10. Xu Hua, Luxiao Chen, Jin Wang+, Jie Li+ and Edgar Wingender+. Identifying cell-specific microRNA transcriptional start sites. Bioinformatics, 2016, Volume 32, Issue 16, Pages 2403–2410
11. Jie Li*, Xu Hua*, Martin Haubrock, Jin Wang+ and Edgar Wingender+. The architecture of the gene regulatory networks of different tissues. Bioinformatics, 2012, Volume 28, Issue 18, Pages i509–i514
