Qingbo Liu, Ph.D.
Professor of Biochemistry and Immunology
School of Life Science and Technology, Southeast University
E-mail: liu_qingbo@outlook.com
Lab/Office Address: 2 Dongda Rd, Pukou District, Nanjing, 210088, China
Education & Training
2004-2008: B.S., School of Life Sciences, Shandong University
2008-2013: Ph.D., Institute of Biophysics, Chinese Academy of Sciences
2014-2019: Postdoctoral Fellow, National Institute of Allergy and Infectious Diseases (NIAID), NIH
2019-2022: Research Fellow, National Institute of Allergy and Infectious Diseases (NIAID), NIH
Academic Appointments
2023-Present: Professor, School of Life Science and Technology, Southeast University
Research Interests
Our research group focuses on the rational design of vaccines and antibodies for viruses that pose significant threats to public health, such as HIV-1 and SARS-CoV-2. We employ structure-based and AI-driven approaches to design antigens and validate their immunogenicity through in vitro assays and preclinical animal models. By studying the interactions and co-evolution of viral surface glycoproteins and neutralizing antibodies, we aim to enhance the antiviral activity of these antibodies for potential clinical use. Our long-term goal is to develop effective interventions that can prevent and treat existing viral infections, while also preparing for emerging pathogens.
Selected Publications
1. Q. Liu. Designing boosting immunogens for HIV-1 vaccine development. Cell Host & Microbe Volume 32 Issue 5 P632-634 (2024)
2. Q. Liu, H. Miao, S. Li, P. Zhang, G. F. Gerber, D. Follmann, H. Jib, S. L. Zeger, D. S. Chertow, T. C. Quinn, M. L. Robinson, T. S. Kickler, R. E. Rothman, K. Z. J. Fenstermacher, E. M. Braunstein, A. L. Cox, P. Farci, A. S. Fauci, and P. Lusso. Anti-PF4 antibodies associated with disease severity in COVID-19, Proceedings of the National Academy of Sciences 119 (47) e2213361119 (2022)
3. Q. Liu, P. Zhang, H. Miao, Y. Lin, Y. D. Kwon, P. D. Kwong, Z. Rikhtegaran-Tehrani, M. S. Seaman, A. L. DeVico, M. M. Sajadi, P. Lusso. Rational engraftment of quaternary-interactive acidic loops for anti-HIV-1 antibody improvement, Journal of Virology Volume 95 Issue 12 e00159-21 (2021)
4. P. Zhang, E. Narayanan, Q. Liu, Y. Tsybovsky, K. Boswell, S. Ding, Z. Hu, D. Follmann, Y. Lin, H. Miao, H. Schmeisser, D. Rogers, S. Falcone, S. M. Elbashir, V. Presnyak, K. Bahl, M. Prabhakaran, X. Chen, E. K. Sarfo, D. R. Ambrozak, R. Gautam, M. A. Martin, J. Swerczek, R. Herbert, D. Weiss, J. Misamore, G. Ciaramella, S. Himansu, G. Stewart-Jones, A. McDermott, R. A. Koup, J. R. Mascola, A. Finzi, A. Carfi, A. S. Fauci & P. Lusso. A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques, Nature Medicine volume 27, 2234–2245 (2021)
5. Q. Liu, Y. Lai, P. Zhang, M. K. Louder, A. Pegu, R. Rawi, M. Asokan, X. Chen, C. Shen, G. Chuang, G.-Y. Chuang, E. S. Yang, H. Miao, Y. Wang, A. S. Fauci, P. D. Kwong, J. R. Mascola, and P. Lusso. Improvement of antibody functionality by structure-guided paratope engraftment, Nature Communications volume 10, Article number: 721 (2019).
6. Q. Liu, P. Acharya, M. A. Dolan, P. Zhang, C. Guzzo, J. Lu, A. Kwon, D. Gururani, H. Miao, T. Bylund, G. Chuang, A. Druz, T. Zhou, W. J Rice, C. Wigge, B. Carragher, C. S. Potter, P. D. Kwong, and P. Lusso. Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer. Nature Structural & Molecular Biology 24, 370–378 (2017)
